Reference : 51. Telmisartan Plus HCTZ vs. Amlodipine Plus HCTZ in older patients with systolic hyper...
Scientific journals : Article
Human health sciences : Urology & nephrology
http://hdl.handle.net/2268/81863
51. Telmisartan Plus HCTZ vs. Amlodipine Plus HCTZ in older patients with systolic hypertension : results from a large ambulatory blood pressure monitoring study
English
Neldam, Steen [ > > ]
Edwards, Colin [ > > ]
The ATHOS study group [ > > ]
Krzesinski, Jean-Marie mailto [Université de Liège - ULg > > Néphrologie >]
Hutunen, M. [ > > ]
Bernard, V. [ > > ]
Schmidt, J. [ > > ]
O'Brien, D. [ > > ]
Santonastosa, M. [ > > ]
de Backer, W. A. [ > > ]
Grey, P. C. [ > > ]
Gomez, P. [ > > ]
2006
American Journal of Geriatric Cardiology
Le Jacq Communications
15
151-160
Yes (verified by ORBi)
International
1076-7460
Darien
CT
[en] Telmisartan ; HCTZ ; Amlodipine ; systolic hypertension ; ABPM
[en] Systolic hypertension often requires combination therapy. Few data exist comparing angiotensin receptor blocker plus diuretic therapy with other combinations in older patients. In a prospective, randomized, open-label, blinded-end point trial, patients (≥60 years of age) with predominantly systolic hypertension received telmisartan 40–80 mg or amlodipine 5–10 mg for 8 weeks, before the addition of hydrochlorothiazide (HCTZ) 12.5 mg for a further 6 weeks. Twenty-four-hour ambulatory blood pressure monitoring showed that telmisartan plus HCTZ (n =448) and amlodipine plus HCTZ (n =424) changed systolic blood pressure for the last 6 hours of the dosing interval by −18.3 and −17.4 mm Hg, respectively (p =0.2520). Over the 24-hour period, telmisartan plus HCTZ was superior (−19.3 and −17.2 mm Hg, respectively; p =0.001) and provided higher systolic control rates (65.9% and 58.3%, respectively; p =0.0175). Adverse events (41.2% and 53.7%, respectively) and discontinuations (5.0% and 11.3%, respectively) were lower (p<0.0001) with telmisartan than with amlodipine, mainly due to peripheral edema (1.2% and 24.3%, respectively).
Professionals
http://hdl.handle.net/2268/81863
10.1111/j.1076-7460.2006.05219.x
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