Reference : Relationship of human follicular diameter with oocyte fertilization and development a...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
Relationship of human follicular diameter with oocyte fertilization and development after in-vitro fertilization or intracytoplasmic sperm injection.
Ectors, Fabien mailto [Université de Liège - ULg > > GIGA-Management : Plate-forme transgénique >]
Vanderzwalmen, P. [> > > >]
Van Hoeck, J. [> > > >]
Nijs, M. [> > > >]
Verhaegen, G. [> > > >]
Delvigne, A. [> > > >]
Schoysman, R. [> > > >]
Leroy, Fernand []
Human Reproduction
Oxford University Press
Yes (verified by ORBi)
United Kingdom
[en] embryo scoring ; folliculogenesis ; ICSI ; IVF ; oocyte
[en] The aim of this work was to evaluate the relationship between follicular size at the time of oocyte retrieval, and the subsequent oocyte competence to be fertilized and to develop in vitro. All the obtained oocytes were classified according to the corresponding volume of aspirated follicular fluid. Aspirated volume of follicular fluid <2 ml corresponded to a follicular diameter <16 mm and constituted the small size group. Volume of follicular fluid from 2 to 6 ml corresponded to a diameter from 16 to 23 mm and constituted the medium size group. The large size group contained follicles with diameter >23 mm and corresponded to an aspirated volume of follicular fluid of >6 ml. A progressive and significant increase in the rates of oocytes with a first polar body was observed from the small size group to the other groups and from the medium to the large size group: 75.3, 85.9 and 95.3% respectively. After classical in-vitro fertilization (IVF), significantly better rates of fertilization and development were obtained in the medium size group compared to the two other groups. Moreover, a positive relationship was observed between follicular diameter and rates of embryos scored as 'good' when oocytes were fertilized by intracytoplasmic sperm injection (ICSI). These results demonstrated that follicular size is positively related to the oocyte ability to be fertilized and to develop. Although oocytes from small follicles gave lower percentages of development probably due to partial oocyte incompetence, they allowed an increase in the total number of embryos scored as 'good'.
Researchers ; Professionals

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