Article (Scientific journals)
The value of machine perfusion perfusate biomakers for predicting kidney transplant outcome
Moers, Cyril; Varnay, Oana C; Van Heurn, Ernest et al.
2010In Transplantation, 90
Peer Reviewed verified by ORBi
 

Files


Full Text
00007890-201011150-00006.pdf
Publisher postprint (777.97 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
machine perfusion; kidney transpl; perfusate biomakers
Abstract :
[en] Background. Retrospective evidence suggests that lactate dehydrogenase, aspartate aminotransferase, total glutathione-S-transferase (GST), alanine-aminopeptidase, N-acetyl- -D-glucosaminidase (NAG), and hearttype fatty acid binding protein (H-FABP) measured during kidney machine perfusion (MP) could have predictive value for posttransplant outcome. However, these data may be biased due to organ discard based on biomarker measurements, and previous analyses were not adjusted for likely confounding factors.Noreliable prospective evidence has been available so far. Nevertheless, some centers already use these biomarkers to aid decisions on accepting or discarding a donor kidney. Methods. From 306 deceased-donor kidneys donated after brain death or controlled cardiac death and included in an international randomized controlled trial, these six biomarkers were measured in the MP perfusate. In this unselected prospective data set, we tested whether concentrations were associated with delayed graft function, primary nonfunction, and graft survival. Multivariate regression models investigated whether the biomarkers remained independent predictors when adjusted for relevant confounding factors. Results. GST, NAG, and H-FABP were independent predictors of delayed graft function but not of primary nonfunction and graft survival. Lactate dehydrogenase, aspartate aminotransferase, and alanine-aminopeptidase had no independent prognostic potential for any of the endpoints. Perfusate biomarker concentrations had no relevant correlation with cold ischemic time or renal vascular resistance on the pump. Conclusions. Increased GST, NAG, or H-FABP concentrations during MP are an indication to adjust posttransplant recipient management. However, this study shows for the first time that perfusate biomarker measurements should not lead to kidney discard. Keywords: Machine perfusion, Kidney transplantation, Perfusate biomarkers, Delayed graft function, Graft survival
Disciplines :
Surgery
Author, co-author :
Moers, Cyril
Varnay, Oana C
Van Heurn, Ernest
Jochmans, Ina
Kirste, Günter R
Rahmel, Axel
Leuvenink, Henri G.D
Squifflet, Jean-Paul ;  Université de Liège - ULiège > Chirurgie abdominale- endocrinienne et de transplantation
Paul, Andreas
Pirenne, Jacques
van Oeveren, Wim
Rakhorst, Gerhard
Ploeg, Rutger J
More authors (3 more) Less
Language :
English
Title :
The value of machine perfusion perfusate biomakers for predicting kidney transplant outcome
Publication date :
November 2010
Journal title :
Transplantation
ISSN :
0041-1337
eISSN :
1534-6080
Publisher :
Lippincott Williams & Wilkins, Hagerstown, United States - Maryland
Volume :
90
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 January 2011

Statistics


Number of views
192 (7 by ULiège)
Number of downloads
2511 (1 by ULiège)

Scopus citations®
 
93
Scopus citations®
without self-citations
57
OpenCitations
 
82

Bibliography


Similar publications



Contact ORBi