Article (Scientific journals)
Identification of BlaR, the signal transducer for β-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 β-lactamase (class D) of Salmonella typhimurium
Zhu, Ying-Fang; Curran, Ivan H. A.; Joris, Bernard et al.
1990In Journal of Bacteriology, 172 (2), p. 1137-1141
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Keywords :
amino acid sequence; bacillus/enzymology/*genetics/metabolism; bacterial proteins; carrier proteins/*genetics/metabolism; enzyme induction; genes, bacterial; genetic vectors; hexosyltransferases; molecular sequence data; muramoylpentapeptide carboxypeptidase/*genetics/metabolism; penicillin-binding proteins; peptidyl transferases; restriction mapping; salmonella typhimurium/enzymology/*genetics; sequence homology, nucleic acid; signal transduction; beta-Lactamases/*biosynthesis/*genetics
Abstract :
[en] The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A beta-lactamase. The protein product, BlaR, has a hydrophilic carboxy region that binds beta-lactams and shows high sequence homology to the class D beta-lactamases, particularly the OXA-2 beta-lactamase of Salmonella typhimurium. The BlaR-beta-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.
Research center :
CIP - Centre d'Ingénierie des Protéines - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Zhu, Ying-Fang;  The State University of New Jersey > Waksman Institute
Curran, Ivan H. A.;  The State University of New Jersey > Waksman Institute
Joris, Bernard ;  Université de Liège - ULiège > Département des sciences de la vie > Physiologie et génétique bactériennes - Centre d'ingénierie des protéines
Ghuysen, Jean-Marie ;  Université de Liège - ULiège > Institut de Chimie > Service de Microbiologie
Lampen, J. Oliver;  Université de Liège - ULiège > Institut de Chimie > Service de Microbiologie
Language :
English
Title :
Identification of BlaR, the signal transducer for β-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 β-lactamase (class D) of Salmonella typhimurium
Publication date :
01 February 1990
Journal title :
Journal of Bacteriology
ISSN :
0021-9193
eISSN :
1098-5530
Publisher :
American Society for Microbiology (ASM), Washington, United States - District of Columbia
Volume :
172
Issue :
2
Pages :
1137-1141
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 January 2011

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