ORBi: Zhu Ying-Fang - Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium

Reference : Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/81269

Title :	Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium
Language :	English
Author, co-author :	Zhu, Ying-Fang [The State University of New Jersey > Waksman Institute > > >]
	Curran, Ivan H. A. [The State University of New Jersey > Waksman Institute > > >]
	Joris, Bernard [Université de Liège - ULg > Département des sciences de la vie > Physiologie et génétique bactériennes - Centre d'ingénierie des protéines >]
	Ghuysen, Jean-Marie [Université de Liège - ULg > Institut de Chimie > Service de Microbiologie > >]
	Lampen, J. O. [Université de Liège - ULg > Institut de Chimie > Service de Microbiologie > >]
Publication date :	1-Feb-1990
Journal title :	Journal of Bacteriology
Publisher :	American Society for Microbiology (ASM)
Volume :	172
Issue/season :	2
Pages :	1137-1141
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0021-9193
e-ISSN :	1098-5530
City :	Washington
Country :	DC
Keywords :	[en] amino acid sequence ; bacillus/enzymology/genetics/metabolism ; bacterial proteins ; carrier proteins/genetics/metabolism ; enzyme induction ; genes, bacterial ; genetic vectors ; hexosyltransferases ; molecular sequence data ; muramoylpentapeptide carboxypeptidase/genetics/metabolism ; penicillin-binding proteins ; peptidyl transferases ; restriction mapping ; salmonella typhimurium/enzymology/genetics ; sequence homology, nucleic acid ; signal transduction ; beta-Lactamases/biosynthesis/genetics
Abstract :	[en] The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A beta-lactamase. The protein product, BlaR, has a hydrophilic carboxy region that binds beta-lactams and shows high sequence homology to the class D beta-lactamases, particularly the OXA-2 beta-lactamase of Salmonella typhimurium. The BlaR-beta-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/81269

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