Reference : Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Identification of BlaR, the signal transducer for beta-lactamase production in Bacillus licheniformis, as a penicillin-binding protein with strong homology to the OXA-2 beta-lactamase (class D) of Salmonella typhimurium
Zhu, Ying-Fang[The State University of New Jersey > Waksman Institute > > >]
[en] The blaR gene of Bacillus licheniformis encodes the signal transducer for induction of the class A beta-lactamase. The protein product, BlaR, has a hydrophilic carboxy region that binds beta-lactams and shows high sequence homology to the class D beta-lactamases, particularly the OXA-2 beta-lactamase of Salmonella typhimurium. The BlaR-beta-lactam complex is stable and may provide the continuing stimulus needed for the prolonged production of the enzyme.