Mitral valve dynamics in a closed-loop model of the cardiovascular system

A cardiovascular and circulatory system (CVS) model has been validated in silico, and in several animal model studies. It accounts for valve dynamics by means of Heaviside function to simulate “open on pressure, close on flow” law. Thus, it does not consider the real time scale of the valve aperture and thus doesn’t fully capture valve dysfunction. This work describes a new coupled model of the cardiovascular system that accounts for progressive mitral valve aperture. Simulations show good correlation with physiologically expected results for healthy or diseased valves. The large number of valve model parameters indicates a need for emerging, lighter and minimal mitral valve models that are readily identifiable to achieve full benefit in real-time use. These results suggest a further use of this model to track, diagnose and control valves pathologies.