ORBi: Hayette Marie-Pierre - A rapid immunochromatographic test (ICT) for serological diagnosis of tuberculosis

Reference : A rapid immunochromatographic test (ICT) for serological diagnosis of tuberculosis


	Document type :	Scientific congresses and symposiums : Poster
	Discipline(s) :	Human health sciences : Laboratory medicine & medical technology Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/80602

Title :	A rapid immunochromatographic test (ICT) for serological diagnosis of tuberculosis
Language :	English
Alternative title :	[fr] Test immuchromatographique rapide pour le diagnostic sérologique de la tuberculose
Author, co-author :	Hayette, Marie-Pierre [Université de Liège - ULg > > Microbiologie médicale >]
	Serpe, K. [Clinique André Renard, Hertsal > Laboratoire > > >]
	Gonissen, Viviane [Hopital du Bois de l'Abbaye, Seraing > Laboratoire > > >]
	Grosjean, Y. [Hopital La Tourelle, Verviers > Laboratoire > > >]
	Carpentier, Michel [Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Laboratoire > Microbiologie médicale > >]
	Rousseaux, Danielle [ > > ]
	De Mol, Patrick [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Microbiologie médicale et virologie médicale >]
Publication date :	28-Nov-1998
Page number :	1x1.5
On invitation :	No
Audience :	National
Event name :	11ème réunion scientifique
Event date :	28 novembre 1998
Event organizer :	Société belge d'infectiologie et de microbiologie clinique
Event place (city) :	Gand (UZ)
Event country :	Belgium
Keywords :	[en] ICT ; tuberculosis ; diagnosis ; infection ; serology ; rapid test
Abstract :	[en] The lCT tuberculosis is an in vitro immunodiagnostic test for the detection of antibodies to Mycobacterium tuberculosis in serum or plasma. This test targets 5 recombinant M tuberculosis proteins, including the 38 and 85 KDa antigens. We evaluated this test on 65 sera from patients with and without TB living in Liege. Patients and methods: This test was performed on two groups : The TB group included 31 patients condidered to have an active tuberculosis : pulmonary (26 cases) or extrapulmonary (5 cases). All of them had at least one sample with positive culture and received anti-tuberculous treatment. The identification of TB strains was performed with Accuprobe M tuberculosis complexe (Gen-Probe). The second group (control group) included 34 patients with the following characteristics: BCG negative nonexposed healthy (19), BCG positive or exposed healthy (2), non-TB respiratory disease (10), atypical TB (3). The identification of the atypical mycobacteria was determined according to the biochemical characteristics or by molecular biology. Results. The sensitivity is 38.7%, the specificity is 94%. The positive predictive value is 85.7% and the negative predictive value is 62,7%. Two false lCT positive results were found in the control group: both patients had a past infection with TB. Conclusion: This test is very easy and rapid to perform, has a good specificity but lacks sensitivity in low prevalence countries. A positive lCT allows same day diagnosis of Mycobacterium tuberculosis infection.
Target :	Professionals
Permalink :	http://hdl.handle.net/2268/80602

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