Reference : Evaluation of low-molecular-weight heparin for the prevention of equine laminitis aft...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/8056
Evaluation of low-molecular-weight heparin for the prevention of equine laminitis after colic surgery
English
de la Rebière de Pouyade, Geoffroy mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Grulke, Sigrid mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Detilleux, Johann mailto [Université de Liège - ULg > Département de productions animales > Génétique quantitative - Epidémiologie et santé publique >]
Salciccia, Alexandra mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Verwilghen, Denis mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Caudron, Isabelle [> >]
Gangl, Monica [> >]
Serteyn, Didier mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
Feb-2009
Journal of Veterinary Emergency and Critical Care
Blackwell Publishing
19
1
113-119
Yes (verified by ORBi)
International
1479-3261
[en] colic ; enoxaparin ; fractionated heparin ; horses ; postoperative intensive care
[en] Objectives – The aim of this study is to describe the prevalence of postoperative laminitis in colic cases and to
determine if low-molecular-weight heparin (LMWH) is effective in preventing this complication.
Design – Retrospective clinical study.
Animals – Client-owned horses.
Interventions – SC administration of enoxaparin during the postoperative period.
Measurements and Main Results – Medical records of 360 horses undergoing surgery for colic and surviving
at least 3 days were evaluated. Fifty-six horses admitted before 1995 did not receive LMWH (control group)
and 304 admitted after 1995 received LMWH as a prophylaxis for laminitis (treatment group). Three grades of
severity were defined for laminitis. Prevalence and severity of laminitis were compared between the 2 groups.
Several parameters recorded on admission (sex, age, breed, site and nature of the disease, heart rate, PCV,
gravity score, and shock score) and the administration of LMWH were tested as risk factors in the
development of laminitis in a logistic regression procedure. Prevalence and grade of laminitis were
significantly lower in the treatment group. Only the absence of LMWH was recognized as a significant risk
factor in the logistic regression model.
Conclusions – The administration of LMWH appears to be effective in the prophylaxis of laminitis following
colic surgery and may be useful in the postoperative management of these horses.
Centre de l’Oxygène, Recherche et Développement - CORD ; Clinique Vétérinaire universitaire, pôle équin, chirurgie et anesthésie des grands animaux
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/8056
10.1111/j.1476-4431.2008.00379.x
http://www.wiley.com/bw/journal.asp?ref=1479-3261

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