ORBi: Herens Christian - Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients.

Reference : Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybr...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Hematology
	To cite this reference:	http://hdl.handle.net/2268/8044

Title :	Deletion of the 5'-ABL region: a recurrent anomaly detected by fluorescence in situ hybridization in about 10% of Philadelphia-positive chronic myeloid leukaemia patients.
Language :	English
Author, co-author :	Herens, Christian [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
	Tassin, Françoise [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
	Lemaire, Véronique [Centre Hospitalier Universitaire de Liège - CHU > > Salles urgences NDB >]
	Beguin, Yves [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
	Collard, E. [> > > >]
	Lampertz, S. [> > > >]
	Croisiau, C. [> > > >]
	Lecomte, Michèle [Université de Liège - ULg > Département de chimie (sciences) > Laboratoire de chimie physique théorique >]
	De Prijk, Bernard [ > > ]
	Longree, L. [> > > >]
	Koulischer, L. [> > > >]
Publication date :	2000
Journal title :	British Journal of Haematology
Publisher :	Blackwell Publishing
Volume :	110
Issue/season :	1
Pages :	214-6
Audience :	International
ISSN :	0007-1048
e-ISSN :	1365-2141
City :	Oxford
Country :	United Kingdom
Keywords :	[en] Adult ; Aged ; Aged, 80 and over ; DNA Probes ; Female ; Fusion Proteins, bcr-abl/genetics ; Gene Deletion ; Humans ; In Situ Hybridization, Fluorescence ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics ; Male ; Middle Aged ; Philadelphia Chromosome
Abstract :	[en] Inclusion of the BCR-ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph+) chronic myeloid leukaemia patients characterized by a 5'-ABL deletion. This anomaly was observed in 5/51 cases (9.8%). Cytological and clinical data suggest that the 5'-ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration.
Permalink :	http://hdl.handle.net/2268/8044

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