Reference : Soluble transferrin receptor as a potential determinant of iron loading in congenital...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/8042
Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis.
English
Cazzola, M. mailto [> > > >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Bergamaschi, G. mailto [> > > >]
Guarnone, R. [> > > >]
Cerani, P. [> > > >]
Barella, S. [> > > >]
Cao, A. [> > > >]
Galanello, R. [> > > >]
1999
British Journal of Haematology
Blackwell Publishing
106
3
752-5
Yes (verified by ORBi)
International
0007-1048
1365-2141
Oxford
United Kingdom
[en] Adolescent ; Adult ; Aged ; Anemia, Dyserythropoietic, Congenital/genetics/metabolism ; Anemia, Sideroblastic/genetics/metabolism ; Child ; Erythropoiesis/genetics/physiology ; Heterozygote ; Humans ; Iron Overload/genetics/metabolism ; Middle Aged ; Mutation/genetics ; Receptors, Transferrin/genetics/metabolism ; beta-Thalassemia/genetics/metabolism
[en] Congenital anaemias due to ineffective erythropoiesis may be associated with excessive iron absorption and progressive iron loading. We investigated whether the soluble transferrin receptor (TfR) level was related to the degree of iron overload in 20 patients with thalassaemia intermedia, six patients with congenital dyserythropoietic anaemia type II (CDA II) and four patients with X-linked congenital sideroblastic anaemia (XLSA). All but two patients had increased serum ferritin levels (median 601 microgram/l, range 105-2855 microgram/l). Multiple regression analysis showed that 62% (P < 0.0001) of the variation in serum ferritin was explained by age and by changes in soluble TfR.
http://hdl.handle.net/2268/8042
10.1046/j.1365-2141.1999.01600.x

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