Article (Scientific journals)
Red blood cell precursor mass as an independent determinant of serum erythropoietin level.
Cazzola, M.; Guarnone, R.; Cerani, P. et al.
1998In Blood, 91 (6), p. 2139-45
Peer Reviewed verified by ORBi
 

Files


Full Text
103.pdf
Publisher postprint (276.42 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Anemia/blood; Anemia, Aplastic/blood; Anemia, Hypochromic/blood/drug therapy; Anemia, Megaloblastic/blood; Antineoplastic Combined Chemotherapy Protocols/pharmacology/therapeutic use; Bone Marrow Transplantation; Erythrocyte Indices; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin/biosynthesis/blood; Feedback; Folic Acid/therapeutic use; Hodgkin Disease/blood/drug therapy; Humans; Iron/therapeutic use; Kidney/metabolism; Receptors, Transferrin/analysis; Transplantation Conditioning; Vitamin B 12/therapeutic use; beta-Thalassemia/blood
Abstract :
[en] Serum erythropoietin (sEpo) concentration is primarily related to the rate of renal production and, under the stimulus of hypoxia, increases exponentially as hemoglobin (Hb) decreases. Additional factors, however, appear to influence sEpo, and in this work, we performed studies to evaluate the role of the red blood cell precursor mass. We first compared the relationship of sEpo with Hb in patients with low versus high erythroid activity. The first group included 27 patients with erythroid aplasia or hypoplasia having serum transferrin receptor (sTfR) levels < 3 mg/L (erythroid activity < 0.6 times normal), while the second one included 28 patients with beta-thalassemia intermedia having sTfR levels > 10 mg/L (erythroid activity > 2 times normal). There was no difference between the two groups with respect to Hb (8.3 +/- 1.6 v 8.0 +/- 1.3 g/dL, P > .05), but sEpo levels were notably higher in patients with low erythroid activity (1,601 +/- 1,542 v 235 +/- 143 mU/mL, P < . 001). In fact, multivariate analysis of variance (ANOVA) showed that, at any given Hb level, sEpo was higher in patients with low erythroid activity (P < .0001). Twenty patients undergoing allogeneic or autologous bone marrow transplantation (BMT) were then investigated. A marked increase in sEpo was seen in all cases at the time of marrow aplasia, disproportionately high when compared with the small decrease in Hb level. Sequential studies were also performed in five patients with iron deficiency anemia undergoing intravenous (IV) iron therapy. Within 24 to 72 hours after starting iron treatment, marked decreases in sEpo (up to one log magnitude) were found before any change in Hb level. Similar observations were made in patients with megaloblastic anemia and in a case of pure red blood cell aplasia. These findings point to an inverse relationship between red blood cell precursor mass and sEpo: at any given Hb level, the higher the number of red blood cell precursors, the lower the sEpo concentration. The most likely explanation for this is that sEpo levels are regulated not only by the rate of renal production, but also by the rate of utilization by erythroid cells.
Disciplines :
Hematology
Author, co-author :
Cazzola, M.
Guarnone, R.
Cerani, P.
Centenara, E.
Rovati, A.
Beguin, Yves  ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Language :
English
Title :
Red blood cell precursor mass as an independent determinant of serum erythropoietin level.
Publication date :
1998
Journal title :
Blood
ISSN :
0006-4971
eISSN :
1528-0020
Publisher :
American Society of Hematology, Washington, United States - District of Columbia
Volume :
91
Issue :
6
Pages :
2139-45
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 March 2009

Statistics


Number of views
94 (2 by ULiège)
Number of downloads
333 (1 by ULiège)

Scopus citations®
 
97
Scopus citations®
without self-citations
80
OpenCitations
 
1

Bibliography


Similar publications



Contact ORBi