Reference : Class IIa histone deacetylases: conducting development and differentiation.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/80271
Class IIa histone deacetylases: conducting development and differentiation.
English
Martin, Maud mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Kettmann, Richard mailto [Université de Liège - ULg > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
Dequiedt, Franck mailto [Université de Liège - ULg > > GIGA-Research - Centre de Bio. Fond. - Section de Biologie cell. et moléc. >]
2009
International Journal of Developmental Biology
University of the Basque Country Press
53
2-3
291-301
Yes (verified by ORBi)
International
0214-6282
Vizcaya
Spain
[en] Animals ; Cell Differentiation/genetics/physiology ; Chondrocytes/metabolism/pathology ; Histone Deacetylases/genetics/metabolism ; Mice ; Models, Biological ; Repressor Proteins/genetics/metabolism
[en] The emergence of specialized cell types and their organisation into organs and tissues involve the temporal modulation of many genes that are essential for coordinating the correct timing of instructive signals. These transcriptional changes are orchestrated with a precision that reminds that of a classical symphony. Extracellular signals are transmitted to key integrators, which then orchestrate activation or repression of specific genes. In the last decade, class IIa HDACs have emerged as crucial regulators in various developmental and differentiation processes. This review focuses on the latest studies that have provided new insights into the biological functions of class IIa HDACs and discusses important aspects of their regulation. Elucidating cellular and molecular mechanisms by which functions of class IIa HDACs are modulated could potentially lead to new therapeutic opportunities for various diseases.
http://hdl.handle.net/2268/80271
10.1387/ijdb.082698mm

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