Reference : Human glioblastoma-initiating cells invade specifically the subventricular zones and ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Surgery
Human health sciences : Oncology
http://hdl.handle.net/2268/80146
Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection.
English
Kroonen, Jérôme [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Nassen, Jessica [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Boulanger, Yves-Gauthier [> >]
Provenzano, Fabian [> >]
Capraro, Valérie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Centre d'oncologie >]
Bours, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Martin, Didier mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurochirurgie >]
Deprez, Manuel [Université de Liège - ULg > > Anatomie pathologique >]
Robe, Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine - Département des sciences biomédicales et précliniques >]
Rogister, Bernard mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
2011
International Journal of Cancer = Journal International du Cancer
Wiley
129
3
574-585
Yes (verified by ORBi)
International
0020-7136
1097-0215
New York
NY
[en] This study reports the subsequent isolation of human glioblatoma cells able to initiate experimental brain tumors, specifically and repeatedly found in the subventricular zones and olfactory bulbs following xenograft in the caudate putamen of immunodeficient mice.In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have been recently described and they were shown to be specifically involved in experimental tumorigenesis. In this study, we show that some human glioblastoma cells injected into the striatum of immunodeficient nude mice exhibit a tropism for the subventricular zones. There and similarily to neurogenic stem cells, these subventricular glioblastoma cells were then able to migrate towards the olfactory bulbs. Finally, the glioblastoma cells isolated from the adult mouse subventricular zones and olfactory bulbs display high tumorigenicity when secondary injected in a new mouse brain. Together, these data suggest that neurogenic zones could be a reservoir for particular cancer-initiating cells.
http://hdl.handle.net/2268/80146
also: http://hdl.handle.net/2268/92533
10.1002/ijc.25709

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