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| Reference : A direct enzyme-linked immunosorbent assay (Elisa) for antibodies to enterobacterial sco... |
| Scientific journals : Article | |||
| Human health sciences : Anesthesia & intensive care | |||
| http://hdl.handle.net/2268/79921 | |||
| A direct enzyme-linked immunosorbent assay (Elisa) for antibodies to enterobacterial score glycolipid and lipid A. Results in Healthy Subjects and in Patients Infected by Gram-Negative Bacteria | |
| English | |
Nys, Monique  [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >] | |
| Damas, Pierre [Université de Liège - ULg > > Soins intensifs >] | |
| Damas, François [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)] | |
| Joassin, L. [> > > >] | |
| Demonty, Jean [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >] | |
| 1987 | |
| Medical Microbiology & Immunology | |
| Springer Science & Business Media B.V. | |
| 176 | |
| 5 | |
| 257-271 | |
| International | |
| 0300-8584 | |
| [en] We have developed an ELISA for IgM and IgG antibodies to the core glycolipid (CGL) of the Re mutant Salmonella minnesota R 595, and to lipid A. Anti-CGL antibodies have been detected in sera from 37% of healthy blood donors, whereas anti-lipid A activities were found in 13% of individuals only. The anti-CGL and anti-lipid A activities were examined in patients in a surgical intensive care unit, selected on the basis of a definite risk of infectious complications due to Gram-negative bacteria. Of the patients who developed such infections, the rate of favourable outcome was significantly higher in patients with either stable positive or increasing anti-CGL activities than in patients found to be negative. Our results provide clear evidence that anti-CGL antibodies contribute to host defence against various Gram-negative bacteria. | |
| Researchers ; Professionals | |
| http://hdl.handle.net/2268/79921 |
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