|Reference : A direct enzyme-linked immunosorbent assay (Elisa) for antibodies to enterobacterial sco...|
|Scientific journals : Article|
|Human health sciences : Anesthesia & intensive care|
|A direct enzyme-linked immunosorbent assay (Elisa) for antibodies to enterobacterial score glycolipid and lipid A. Results in Healthy Subjects and in Patients Infected by Gram-Negative Bacteria|
|Nys, Monique [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]|
|Damas, Pierre [Université de Liège - ULg > > Soins intensifs >]|
|Damas, François [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)]|
|Joassin, L. [> > > >]|
|Demonty, Jean [Centre Hospitalier Universitaire de Liège - CHU > > Maladies infectieuses et médecine interne générale >]|
|Medical Microbiology & Immunology|
|Springer Science & Business Media B.V.|
|[en] We have developed an ELISA for IgM and IgG antibodies to the core glycolipid (CGL) of the Re mutant Salmonella minnesota R 595, and to lipid A. Anti-CGL antibodies have been detected in sera from 37% of healthy blood donors, whereas anti-lipid A activities were found in 13% of individuals only. The anti-CGL and anti-lipid A activities were examined in patients in a surgical intensive care unit, selected on the basis of a definite risk of infectious complications due to Gram-negative bacteria. Of the patients who developed such infections, the rate of favourable outcome was significantly higher in patients with either stable positive or increasing anti-CGL activities than in patients found to be negative. Our results provide clear evidence that anti-CGL antibodies contribute to host defence against various Gram-negative bacteria.|
|Researchers ; Professionals|
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