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| Reference : Cystatin C is a reliable marker for estimation of glomerular filtration rate in renal tr... |
| Scientific journals : Article | |||
| Human health sciences : Laboratory medicine & medical technology | |||
| http://hdl.handle.net/2268/79414 | |||
| Cystatin C is a reliable marker for estimation of glomerular filtration rate in renal transplantation: validation of a new turbidimetric assay using monospecific sheep antibodies | |
| English | |
| Bargnoux, A. S. [> >] | |
Cavalier, Etienne  [Université de Liège - ULg > > Chimie médicale >] | |
| Cristol, J. P. [> >] | |
| Simon, N. [> >] | |
| Dupuy, A. M. [> >] | |
| Garrigue, V. [> >] | |
| Delanaye, Pierre [Université de Liège - ULg > > Néphrologie >] | |
| Mourad, G. [> >] | |
| Feb-2011 | |
| Clinical Chemistry & Laboratory Medicine | |
| Walter de Gruyter | |
| 49 | |
| 2 | |
| 265-70 | |
| International | |
| 1434-6621 | |
| Berlin | |
| Germany | |
| [en] Cystatin C ; renal transplantation ; glomerular filtration rate ; predictive equation | |
| [en] Background: The potential use of Cystatin C was recently assessed in kidney transplantation.
A new particle-enhanced turbidimetric immunoassay (PETIA) that uses sheep antibodies (Binding Site Human Cystatin C immunoassay) has been developed. Analytical performance of this new assay was evaluated. Clinical relevance was determined by comparison with a reference method in a cohort of kidney transplant patients. Patients and methods: First, the analytical performance of the Binding Site cystatin C kit was tested on SPAPLUS® and Hitachi® analyzers. Second, a comparison study was performed using SPAPLUS® analyzer against two other cystatin C methods (the Siemens-PENIA method on BNII® and the Dako-PETIA application on Olympus AU640®). Third, the glomerular filtration rate (GFR) was estimated using several predictive cystatin C- and creatinine-based equations and compared to GFR measured by an isotopic method (99mTc-DTPA). These predictive algorithms were analyzed with respect to bias, precision and accuracy. Results: Total intra-assay and inter-assay coefficients of variation were below 5%. Values obtained with the SPAPLUS® correlated with the Siemens-PENIA and the Dako-PETIA methods. The creatinine and cystatin C-based equation allowed reliable assessment of GFR in our population of renal transplantation. Conclusions: The use of algorithms based on cystatin C and creatinine could provide a reliable estimate of GFR in kidney transplantation. | |
| http://hdl.handle.net/2268/79414 |
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