Reference : Patient specific identification of the cardiac driver function in a cardiovascular sy...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/78997
Patient specific identification of the cardiac driver function in a cardiovascular system model.
English
Hann, C. E. [> > > >]
Revie, J. [> > > >]
Stevenson, D. [> > > >]
Heldmann, S. [> > > >]
Desaive, Thomas mailto [Université de Liège - ULg > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles - Département d'astrophys., géophysique et océanographie (AGO) >]
Froissart, C. B. [> > > >]
Lambermont, Bernard mailto [Université de Liège - ULg > > Frais communs médecine >]
Ghuysen, Alexandre mailto [Université de Liège - ULg > Département des sciences de la santé publique > Réanimation - Urgence extrahospitalière >]
Kolh, Philippe mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, humaines et path. >]
Shaw, G. M. [> > > >]
Chase, J. G. [> > > >]
2011
Computer Methods & Programs in Biomedicine
Elsevier Scientific
Yes (verified by ORBi)
International
0169-2607
Limerick
Ireland
[en] The cardiac muscle activation or driver function, is a major determinant of cardiovascular dynamics, and is often approximated by the ratio of the left ventricle pressure to the left ventricle volume. In an intensive care unit, the left ventricle pressure is usually never measured, and the left ventricle volume is only measured occasionally by echocardiography, so is not available real-time. This paper develops a method for identifying the driver function based on correlates with geometrical features in the aortic pressure waveform. The method is included in an overall cardiovascular modelling approach, and is clinically validated on a porcine model of pulmonary embolism. For validation a comparison is done between the optimized parameters for a baseline model, which uses the direct measurements of the left ventricle pressure and volume, and the optimized parameters from the approximated driver function. The parameters do not significantly change between the two approaches thus showing that the patient specific approach to identifying the driver function is valid, and has potential clinically.
http://hdl.handle.net/2268/78997
10.1016/j.cmpb.2010.06.005
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

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