Reference : SPATIO-TEMPORAL LOCALIZATION OF BETA TUBULIN III IN THE ORGAN OF CORTI AND IN THE SPI...
Scientific congresses and symposiums : Poster
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/78629
SPATIO-TEMPORAL LOCALIZATION OF BETA TUBULIN III IN THE ORGAN OF CORTI AND IN THE SPIRAL GANGLIA BETWEEN THE EMBRYONIC DAY (E18) AND THE POST-NATAL DAY (P25) IN RAT.
English
[en] Localisation spatio-temporelle de tubuline beta III au sein l'organe de Corti et au niveau du ganglion spiral entre le 18e jours embryonnaires (E18) et le 25e jours post-natal (P25) chez le rat
Johnen, Nicolas mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Thelen, Nicolas mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Cloes, Marie mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
22-Oct-2010
A0
No
No
National
Neuroimmunology
22 octobre 2010
the Belgian Society for Cell and Developmental Biology, BSCDB autumn meeting
Hasselt
Belgium
[en] Auditory Organ ; Cytoskeleton ; Development
[en] The mammalian auditory organ, the organ of Corti (OC), is composed of mechanosensory hair cells and nonsensory supporting cell types. Based on their morphology and physiology, at least two types of sensory cells can be identified in the OC: inner and outer hair cells. The structure of this organ is well reported in adult but its development is still little-known.
By using confocal microscopy, we studied the spatial-temporal distribution of beta tubulin III during the differentiation of the OC in rat from the embryonic day 18 (E18) to the postnatal day (P25).
The beta tubulin III is typical for neural cells in the OC. We observed that beta III tubulin is present in the extensions innerving the row of inner hair cells at E18. At E19, the extensions innerving the inner hair cells and the two first rows of outer hair cells were immunolabelled. From E21 to P25, all of hair cells were connected to the spiral ganglion. In the latter, the intensity of immunolabelling decreased between E18 to P25 and the labelling only concerned some cells.
These results reveal that beta III tubulin appears before birth in the nervous extensions connecting the sensory cells of the OC according to a modiolar-to-striolar gradient. In the spiral ganglia, the labelling progressively decreases during its development.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Spatio-temporal localization of the cytoskeleton during auditory organ development in mammalia.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/78629

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
nicolas johnen poster.pdfPublisher postprint773.57 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.