Reference : Effect of an intravenous infusion of lidocaine on cisatracurium-induced neuromuscular bl...
Scientific journals : Article
Human health sciences : Anesthesia & intensive care
http://hdl.handle.net/2268/78336
Effect of an intravenous infusion of lidocaine on cisatracurium-induced neuromuscular block duration: a randomized-controlled trial.
English
Hans, Grégory mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Defresne, Aline [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Ki, Bertille [> > > >]
Bonhomme, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Kaba, Abdourahmane mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Legrain, Caroline [Centre Hospitalier Universitaire de Liège - CHU > > Soins intensifs >]
Brichant, Jean-François mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation >]
Hans, Pol [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
2010
Acta Anaesthesiologica Scandinavica
Blackwell Munksgaard
54
10
1192-6
Yes (verified by ORBi)
International
0001-5172
1399-6576
Oxford
United Kingdom
[en] BACKGROUND: Intravenous lidocaine can be used intraoperatively for its analgesic and antihyperalgesic properties but local anaesthetics may also prolong the duration of action of neuromuscular blocking agents. We hypothesized that intravenous lidocaine would prolong the time to recovery of neuromuscular function after cisatracurium. METHODS: Forty-two patients were enrolled in this randomized, double-blind, placebo-controlled study. Before induction, patients were administered either a 1.5 mg/kg bolus of intravenous lidocaine followed by a 2 mg/kg/h infusion or an equal volume of saline. Anaesthesia was induced and maintained using propofol and remifentanil infusions. After loss of consciousness, a 0.15 mg/kg bolus of cisatracurium was administered. No additional cisatracurium injection was allowed. Neuromuscular function was assessed every 20 s using kinemyography. The primary endpoint was the time to spontaneous recovery of a train-of-four (TOF) ratio >/= 0.9. RESULTS: The time to spontaneous recovery of a TOF ratio >/= 0.9 was 94 +/- 15 min in the control group and 98 +/- 16 min in the lidocaine group (P=0.27). CONCLUSIONS: No significant prolongation of spontaneous recovery of a TOF ratio >/= 0.9 after cisatracurium was found in patients receiving intravenous lidocaine.
http://hdl.handle.net/2268/78336
10.1111/j.1399-6576.2010.02304.x
(c) 2010 The Authors. Journal compilation (c) 2010 The Acta Anaesthesiologica Scandinavica Foundation.

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
543.pdfPublisher postprint249.43 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.