Article (Scientific journals)
Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process
Hale, K. J.; Frigerio, M.; Manaviazar, S. et al.
2003In Organic Letters, 5 (4), p. 499-502
Peer Reviewed verified by ORBi
 

Files


Full Text
hale_organLett_03.pdf
Publisher postprint (77.79 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] [GRAPHICS] The synthesis of two truncated bryostatin analogues 2 and 3 is described. High-field NMR measurements on the C-ring analogue 3 in (CH3CN)-H-2 containing 25% (H2O)-H-2 have shown that it binds to the CRD2 of human PKC-alpha at virtually the same position as phorbol-13-acetate (PA) and bryostatin 1 (1). NMR titration studies have also revealed that 3 binds to the CRD2 with a potency similar in magnitude to PA but much less potently than 1.
Disciplines :
Chemistry
Author, co-author :
Hale, K. J.
Frigerio, M.
Manaviazar, S.
Hummersone, M. G.
Fillingham, I. J.
Barsukov, I. G.
Damblon, Christian ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie biologique structurale
Gescher, A.
Roberts, G. C. K.
Language :
English
Title :
Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process
Publication date :
2003
Journal title :
Organic Letters
ISSN :
1523-7060
eISSN :
1523-7052
Publisher :
American Chemical Society
Volume :
5
Issue :
4
Pages :
499-502
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 November 2010

Statistics


Number of views
50 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
22
Scopus citations®
without self-citations
19
OpenCitations
 
15

Bibliography


Similar publications



Contact ORBi