Reference : Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC...
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/77941
Synthesis of a simplified bryostatin C-ring analogue that binds to the CRD2 of human PKC-alpha and construction of a novel BC-analogue by an unusual Julia olefination process
English
Hale, K. J. [> > > >]
Frigerio, M. [ > > ]
Manaviazar, S. [> > > >]
Hummersone, M. G. [> > > >]
Fillingham, I. J. [> > > >]
Barsukov, I. G. [> > > >]
Damblon, Christian mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie biologique structurale >]
Gescher, A. [> > > >]
Roberts, G. C. K. [> > > >]
2003
Organic Letters
American Chemical Society
5
4
499-502
Yes (verified by ORBi)
1523-7060
1523-7052
[en] [GRAPHICS] The synthesis of two truncated bryostatin analogues 2 and 3 is described. High-field NMR measurements on the C-ring analogue 3 in (CH3CN)-H-2 containing 25% (H2O)-H-2 have shown that it binds to the CRD2 of human PKC-alpha at virtually the same position as phorbol-13-acetate (PA) and bryostatin 1 (1). NMR titration studies have also revealed that 3 binds to the CRD2 with a potency similar in magnitude to PA but much less potently than 1.
http://hdl.handle.net/2268/77941
10.1021/ol027392u

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