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| Reference : A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier... |
| Scientific journals : Article | |||
| Human health sciences : General & internal medicine | |||
| http://hdl.handle.net/2268/77727 | |||
| A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier Added L-P-[18f]Fluorophenylalanine | |
| English | |
Lemaire, Christian  [Université de Liège - ULg > > Centre de recherches du cyclotron >] | |
| Guillaume, M. [> > > >] | |
| Christiaens, Léon [Université de Liège - ULg > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences) >] | |
| Palmer, A. J. [> > > >] | |
| Cantineau, R. [> > > >] | |
| 1987 | |
| International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes | |
| 38 | |
| 12 | |
| 1033-8 | |
| International | |
| 0883-2889 | |
| [en] L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water. The L-form of the [18F]fluoroamino acid can be separated on an analytical scale chiral column. A typical production run of 22.2 GBq (600 mCi) of 18F obtained after a 10 microA.h bombardment of 18 MeV protons on 99.8% 18O-enriched water leads to a batch of 1.11 GBq (30 mCi) of NCA L-p-[18F]fluorophenylalanine after a total synthesis time of 120 min. | |
| http://hdl.handle.net/2268/77727 |
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