|Reference : A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier...|
|Scientific journals : Article|
|Human health sciences : General & internal medicine|
|A New Route for the Synthesis of [18f]Fluoroaromatic Substituted Amino Acids: No Carrier Added L-P-[18f]Fluorophenylalanine|
|Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]|
|Guillaume, M. [> > > >]|
|Christiaens, Léon [Université de Liège - ULg > Services généraux (Faculté des sciences) > Relations académiques et scientifiques (Sciences) >]|
|Palmer, A. J. [> > > >]|
|Cantineau, R. [> > > >]|
|International Journal of Radiation Applications and Instrumentation. Part A : Applied Radiation and Isotopes|
|[en] L-p-[18F]fluorophenylalanine was designed as a potential marker for probing protein synthesis in the human brain by positron emission tomography. This radiotracer has been synthesized using nucleophilic displacement of the activated nitro group of p-nitrobenzaldehyde by NCA 18F- obtained from the 18O (p, n) reaction on enriched water. The L-form of the [18F]fluoroamino acid can be separated on an analytical scale chiral column. A typical production run of 22.2 GBq (600 mCi) of 18F obtained after a 10 microA.h bombardment of 18 MeV protons on 99.8% 18O-enriched water leads to a batch of 1.11 GBq (30 mCi) of NCA L-p-[18F]fluorophenylalanine after a total synthesis time of 120 min.|
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