[en] The 35Cl(alpha, n)38K nuclear reaction was developed for the routine cyclotron production of repeated multimillicurie batches of 38K for dynamic studies of regional tissue perfusion with positron emission tomography. The objective is to make this isotope available as an alternative to the use of [13N]NH3 and 82Rb for the investigation of flow in experimental and clinical use. A sodium chloride powder target mounted on a water-cooled nickel backing is bombarded with 26 MeV helium-4 ions at a maximum beam current of 25 microA. The target is remotely disconnected from the bombardment port, transported to a hot cell and entirely processed by a computer-controlled system within a total time of less than 4 min. The final pyrogen-free isotonic and sterile solution of 38K has a radionuclidic purity of more than 99.99%. A typical yield of 19 +/- 2 mCi of 38K is obtained at the end of a 30 min bombardment at 10 microA. The production rate at saturation can therefore be estimated to 2.05 +/- 0.2 mCi/microA.
Disciplines :
General & internal medicine
Author, co-author :
Guillaume, Marcel; Université de Liège - ULiège > Centre de recherches du cyclotron
Bergmann, Hack, Tewson, Welch, Sobel (1980) The dependance of accumulation of [13N]NH3 by myocardium on metabolic factors and its implications for quantitative assessment of perfusion. Circulation 61:34.
Brihaye, Guillaume, O'Brien, Raets, De Landsheere, Rigo (1987) Preparation and evaluation of a hydrous tin (IV) oxide 82Sr/82Rb medical generator system for continuous elution. Appl. Radiat. Isot. 38:213.
Daube, Nickles (1985) Development of myocardial perfusion tracers for positron emission tomography. Int. J. Nucl. Med. Biol. 12:303.
De Landsheere, Brihaye, Chevigne, Guillaume, Lamotte, Larock, Quaglia, Rigo (1982) Etude de la distribution myocardique du rubidium-82 par tomographie à positons. J. Biophys. Med. Nucl. 6:205.
Goldstein (1986) Rubidium-82 kinetics after coronary occlusion: temporal relation of net myocardial accumulation and viaibility in open-chested dogs. J. Nucl. Med. 27:1456.
Gould (1978) Noninvasive assessment of cornory stenoses with myocardial perfusion imaging during pharmacologic coronary vasodilatation. I. Physiological basis and experimental validation. Am. J. Cardiol. 41:267.
Guillaume (1976) Production en routine par cyclotron de fluor-18 et potassium-43 à usage medical au moyen d'une cible gazeuse télécommandée. Nucl. Instrum. Methods 136:185.
Helus, Gasper, Maier-Borst (1980) Routine production of 38K for medical use. J. Radioanal. Chem. 55:191.
Hurst, Walke (1937) The induced radioactivity of potassium. Phys. Rev. 51:1033.
Jones (1987) Clinical uses of 82Sr/82Rb generators. Appl. Radiat. Isot. 38:171.
Kearfott (1982) Radiations absorbed dose estinates for positron emission tomography (PET), 38K, 81Rb, 82Rb and 130CS. J. Nucl. Med. 23:1128.
Lambrecht, Hara, Gallagher, Wolf, Ansari, Atkins (1978) Cyclotron isotopes and radiopharmaceuticals XXVIII. Production of potassium-38 for myocardial perfusion studies. Int. J. Appl. Radiat. Isot. 29:667.
Lockwood (1980) Absorbed doses of radiation after an intravenous injection of N-13 ammonia in man. J. Nucl. Med. 21:276.
Maziere, Loch, Steinling, Comar (1986) Stable labelling of serum albumin microspheres with gallium-68. Appl. Radiat. Isot. 37:360.
Mullani, Goldstein, Gould, Marani, Fisher, O'Brien, Loberg (1983) Myocardial perfusion with rubidium-82. 1. Measurement of extraction fraction and flow with external detectors. J. Nucl. Med. 24:898.
Myers (1973) Radiopotassium-38 for in-vivo studies of dynamic processes. J. Nucl. Med. 14:359.
Rauch, Helus, Grunze, Braunwell, Mall, Hasselbach, Kubler (1985) Kinetics of 13N-ammonia uptake in myocardial single cells indicating potential limitations in its applicability as a marker of myocardial blood flow. Circulation 71:387.
Robinson Short-lived Radionuclides , The American Chemical Society, Washington, U.S.A; 1985, 437.
Schelbert, Phelps, Hoffman, Huang, Selin, Kuhl (1979) Regional myocardial perfusion assessed with computerized axial N-13 labeled ammonia and positron emission tomography. Am. J. Cardiol. 43:209.
Schelbert, Phelps, Huang, McDonald, Hanssen, Selin, Kuhl (1981) N-13 ammonia as an indicator of myocardial blood flow. Circulation 63:1259.
Selwyn, Allan, L'Abbate, Horlock, Cammici, Clark, O'Brien, Grant (1982) Relation between regional myocardial uptake of rubidium-82 and perfusion: absolute reduction of cation uptake in ischemia. Am. J. Cardiol. 50:112.
Selwyn, Shea, Foale, Deanfield, Wilson, De Landsheere, Turton, Brady, Pike, Brooks (1986) Organ blood flow in patients with myocardial infarction-measurements using the microsphere principle. Circulation 73:432.
Shah, Schelbert, Schwaiger, Henze, Hansen, Selin, Huang (1985) Measurement of regional myocardial blood flow with N-13 ammonia and positron emission tomography in intact dogs. J. Am. Coll. Cardiol. 5:92.
Wilson, Shea, De Landsheere, Turton, Brady, Deanfield, Selwyn (1984) Validation of quantitation of myocardial blood flow in vivo with 11C-labelled human albumin microspheres and positron emission tomography. Circulation 70:717.
