Article (Scientific journals)
Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans.
Michel, Jérôme; Martin-Ventura, J. L.; Egido, J. et al.
2011In Cardiovascular Research
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Abstract :
[en] Aneurysm of the abdominal aorta (AAA) is a particular, specifically localized form of atherothrombosis, providing a unique human model of this disease. The pathogenesis of AAA is characterized by a breakdown of the extracellular matrix due to an excessive proteolytic activity, leading to potential arterial wall rupture. The roles of matrix metalloproteinases and plasmin generation in progression of AAA have been demonstrated both in animal models and in clinical studies. In the present review, we highlight recent studies addressing the role of the haemoglobin-rich, intraluminal thrombus and the adventitial response in the development of human AAA. The intraluminal thrombus exerts its pathogenic effect through platelet activation, fibrin formation, binding of plasminogen and its activators, and trapping of erythrocytes and neutrophils, leading to oxidative and proteolytic injury of the arterial wall. These events occur mainly at the intraluminal thrombus-circulating blood interface, and pathological mediators are conveyed outwards, where they promote matrix degradation of the arterial wall. In response, neo-angiogenesis, phagocytosis by mononuclear cells, and a shift from innate to adaptive immunity in the adventitia are observed. Abdominal aortic aneurysm thus represents an accessible spatiotemporal model of human atherothrombotic progression towards clinical events, the study of which should allow further understanding of its pathogenesis and the translation of pathogenic biological activities into diagnostic and therapeutic applications.
Disciplines :
Surgery
Author, co-author :
Michel, Jérôme ;  Université de Liège - ULiège > Ressources immobilières > ARI : Forêts et voiries
Martin-Ventura, J. L.
Egido, J.
Sakalihasan, Natzi ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Treska, V.
Lindholt, J.
Allaire, E.
Thorsteinsdottir, U.
Cockerill, G.
Swedenborg, Jesper
Language :
English
Title :
Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans.
Publication date :
2011
Journal title :
Cardiovascular Research
ISSN :
0008-6363
eISSN :
1755-3245
Publisher :
Elsevier Science, Amsterdam, Netherlands
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 March 2011

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