Reference : Type II collagen markers in osteoarthritis: what do they indicate?
Scientific journals : Article
Human health sciences : Rheumatology
http://hdl.handle.net/2268/75563
Type II collagen markers in osteoarthritis: what do they indicate?
English
Henrotin, Yves mailto [Université de Liège - ULg > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) - Didactique des sciences de la santé - Pathologie générale et physiopathologie >]
Addison, Shelby [> > > >]
Kraus, Virginia [> > > >]
Deberg, Michelle mailto [Université de Liège - ULg > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.) >]
2007
Current Opinion in Rheumatology
Lippincott Williams & Wilkins
19
5
444-50
Yes
International
1040-8711
1531-6963
Philadelphia
PA
[en] biomarkers ; cartilage ; osteoarthritis ; Animals ; Biological Markers ; Cartilage/metabolism ; Collagen Type II/chemistry/metabolism/urine ; Disease Models, Animal ; Humans ; Osteoarthritis/diagnosis/drug therapy/physiopathology
[en] PURPOSE OF REVIEW: We provide a critical review of recent in-vitro, animal and human clinical studies on type II collagen biomarkers. In describing the human studies, we have applied the BIPED (burden of disease, investigative, prognostic, efficacy of intervention, and diagnostic) classification scheme recently proposed by the Osteoarthritis Biomarkers Network (a consortium of five US National Institutes of Health designated sites). Based on this analysis, we propose an update to the classification of the type II collagen biomarkers. RECENT FINDINGS: Various type II collagen epitopes have been described as potential biomarkers for osteoarthritis. Some have demonstrated ability in the following areas: classification of individuals as either diseased or nondiseased; assessment of severity or extent of osteoarthritis; prediction of future onset of osteoarthritis among those without osteoarthritis at baseline or the progression of osteoarthritis among those with existing disease; and monitoring treatment efficacy. SUMMARY: Type II collagen biomarkers provide useful information for clinical and research applications. Furthermore, they are promising tools for the monitoring the influence of drug treatment on cartilage metabolism in joint diseases such as osteoarthritis.
http://hdl.handle.net/2268/75563
also: http://hdl.handle.net/2268/77356
10.1097/BOR.0b013e32829fb3b5

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