[en] Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3b-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, b-sitosterol, a-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Block, Sébastien; Université Catholique de Louvain (UCL) > Laboratoire de Pharmacognosie > Unité CHAM
Baccelli, Chiara; Université Catholique de Louvain (UCL) > Laboratoire de Pharmacognosie > Unité CHAM
Tinant, Bernard; Université Catholique de Louvain (UCL) > Département de Chimie > Unité CSTR
Van Meervelt, Luc; Katholieke Universiteit Leuven (KUL) > Biomolecular Architecture, Chemistry Department
Rozenberg, Raoul; Université Catholique de Louvain (UCL) > Laboratoire de Spectrométrie de Masse
Habib Jiwan, Jean-Louis; Université Catholique de Louvain (UCL) > Laboratoire de Spectrométrie de Masse
Llabres, Gabriel ; Université de Liège - ULiège > Département de physique > Département de physique
De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques
Quetin-Leclercq, Joëlle; Université Catholique de Louvain (UCL) > Laboratoire de Pharmacognosie > Unité CHAM
Language :
English
Title :
Diterpenes from the leaves of Croton Zambesicus
Publication date :
17 February 2004
Journal title :
Phytochemistry
ISSN :
0031-9422
eISSN :
1873-3700
Publisher :
Pergamon Press, New York, United States - New York
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