Bayes Theorem; Hantavirus/classification/isolation & purification; Humans; Phylogeny; Species Specificity
Abstract :
[en] Hantaviruses belong to the Bunyaviridae family. While usually hosted by wild mammals, they are potentially pathogenic for humans, and several serologically distinct groups associated with different syndromes have been identified. Yet, investigations have mostly been conducted where human infections by hantaviruses constitute a real and well-identified public health problem, i.e., the holarctic and neotropical areas. Some hantaviruses have also been described from a Suncus murinus in India and a Bandicota indica in Thailand. In addition, recent investigations in Cambodia revealed new Hantavirus types. More recently, two new Hantavirus species were described: Sangassou from a Hylomyscus simus, and Tanganya from a Crocidura theresae, both from Africa (Guinea), thus strongly questioning the current views about geographic range, evolution, and epidemiology of hantaviruses. In such a framework, we have conducted a survey of Hantavirus diversity in Southeast Asia which allows us to isolate the Thailand virus and address questions about the taxonomy of their rodent hosts. Here we present a molecular analysis of representatives of all currently known Hantavirus species, thus allowing the comparison between the newly described ones with a large range sample of rodent hantaviruses. Our results clearly point to the presence of a particular lineage of hantaviruses in Southeast Asia. It also strongly suggests that new viruses, additional mammalian hosts and different related syndromes in humans are likely to be discovered in the near future, particularly in Southeast Asia and in Africa, where Muridae rodents are highly diversified. Furthermore, additional work is also urgently needed to investigate the hantaviruses associated with Crociduridae and Soricidae.
Disciplines :
Zoology
Author, co-author :
Henttonen, Heikki
Buchy, Philippe
Suputtamongkol, Yupin
Jittapalapong, Sathaporn
Herbreteau, Vincent
Laakkonen, Juha
Chaval, Yannick
Galan, Maxime
Dobigny, Gauthier
Charbonnel, Nathalie
Michaux, Johan ; Université de Liège - ULiège > Département des sciences de la vie > Génétique
Schmaljohn, C.A., Schmaljohn, A., Dalrymple, J., Hantaan virus M RNA: Coding strategy, nucleotide sequence, and gene order (1987) Virology, 157, pp. 31-39. , &
Childs, J.E., Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States (1994) J. Infect. Dis., 169, pp. 1271-1280
Herbreteau, V., Gonzalez, J.P., Hugot, J.P., Implication of phylogenetic systematics of rodent-borne hantaviruses on their distribution (2006) Ann. N. Y. Acad. Sci., 1081, pp. 39-56. , &
Dekonenko, A., Genetic similarity of Puumala viruses found in Finland and western Siberia and of the mitochondrial DNA of their rodent hosts suggests a common evolutionary origin (2003) Infect. Gen. Evol., 3, pp. 245-257
Hugot, J.P., Genetic analysis of Thailand hantavirus in Bandicota indica trapped in Thailand (2006) Virology J., 3, pp. 72-81
Klempa, B., Hantavirus in African wood mouse, Guinea (2006) Emerg. Infect. Dis., 12, pp. 838-840
Klempa, B., Novel Hantavirus sequences in shrew, Guinea (2007) Emerg. Infect. Dis., 13, pp. 520-522
Song, J.-W., Thottapalayam virus, a prototype shrewborne hantavirus (2007) Emerg. Infect. Dis., 13, pp. 1-15
Reynes, J.M., Evidence of the presence of Seoul virus in Cambodia (2003) Microbes Infect., 5, pp. 769-773
Carey, D., Thottapalayam virus: A presumptive arbovirus isolated from a shrew in India (1971) Indian J. Med. Res., 59, pp. 1758-1760
Xiao, S.Y., Phylogenetic analyses of virus isolates in the genus Hantavirus, family Bunyaviridae (1994) Virology, 198, pp. 205-217
Pattamadilok, S., Geographical distribution of hantaviruses in Thailand and potential human health significance of Thailand virus (2006) Amer. J. Trop. Med. Hyg., 75, pp. 994-1002
Huelsenbeck, J.P., Ronquist, F., MRBAYES: Bayesian inference of phylogeny (2001) Bioinformatics, 17, pp. 754-755. , &
Swofford, D.L., PAUP*. Phylogenetic Analysis Using Parsimony (And Other Methods)., , Version 4. 0b10 2001. Sinauer. Sunderland, MA