Antineoplastic Agents, Phytogenic/chemistry/isolation & purification/pharmacology; Cell Line; Croton/chemistry; Diterpenes/chemistry/isolation & purification/pharmacology; Drug Screening Assays, Antitumor; Hela Cells; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Leaves/chemistry
Abstract :
[en] The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 ùg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Block, Sebastien
Stevigny, Caroline
De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques
de Hoffmann E
Llabres, Gabriel ; Université de Liège - ULiège > Département de physique > Département de physique
Adjakidje, V.
Quetin-Leclercq, Joelle
Language :
English
Title :
Ent-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus
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