Reference : Ent-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/77091
Ent-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus
English
Block, Sebastien [> > > >]
Stevigny, Caroline [ > > ]
Gillet, Marie-Claire mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
de Hoffmann E [ > > ]
Llabres, Gabriel mailto [Université de Liège - ULg > Département de physique > Département de physique >]
Adjakidje, V. [ > > ]
Quetin-Leclercq, Joelle [ > > ]
2002
Planta Medica
68
647-649
Yes
International
[en] Antineoplastic Agents, Phytogenic/chemistry/isolation & purification/pharmacology ; Cell Line ; Croton/chemistry ; Diterpenes/chemistry/isolation & purification/pharmacology ; Drug Screening Assays, Antitumor ; Hela Cells ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Leaves/chemistry
[en] The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 ùg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.
Researchers
http://hdl.handle.net/2268/77091

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