Reference : Ent-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus

	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Multidisciplinary, general & others
	To cite this reference:	http://hdl.handle.net/2268/77091

Title :	Ent-Trachyloban-3beta-ol, a new cytotoxic diterpene frm Croton zambesicus
Language :	English
Author, co-author :	Block, Sebastien [> > > >]
	Stevigny, Caroline [ > > ]
	Gillet, Marie-Claire [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie - Département des sciences biomédicales et précliniques >]
	de Hoffmann E [ > > ]
	Llabres, Gabriel [Université de Liège - ULg > Département de physique > Département de physique >]
	Adjakidje, V. [ > > ]
	Quetin-Leclercq, Joelle [ > > ]
Publication date :	2002
Journal title :	Planta Medica
Volume :	68
Pages :	647-649
Audience :	International
Keywords :	[en] Antineoplastic Agents, Phytogenic/chemistry/isolation & purification/pharmacology ; Cell Line ; Croton/chemistry ; Diterpenes/chemistry/isolation & purification/pharmacology ; Drug Screening Assays, Antitumor ; Hela Cells ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Leaves/chemistry
Abstract :	[en] The dichloromethane extract of leaves of Croton Zambesicus (Euphorbiaceae) showing in vitro cytotoxicity against huma cervix carcinoma cells was investigated in order to identify its active compounds. A bio-guided fractionation by HSCCC followed by MPLC led us to isolate a trachylobane diterpene, ent-trachyloban-3beta-ol, with cytotoxic properties (IC50 on HeLa cells = 7.3 ùg/ml). This is the first report on the cytotoxicity of a trachylobane diterpene.
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/77091

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