Article (Scientific journals)
Do clinical factors help to predict disease course in inflammatory bowel disease?
Louis, Edouard; Belaiche, Jacques; Reenaers, Catherine
2010In World Journal of Gastroenterology, 16 (21), p. 2600-3
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Keywords :
Age of Onset; Disease Progression; Humans; Inflammatory Bowel Diseases/pathology/physiopathology/therapy; Middle Aged; Smoking/adverse effects
Abstract :
[en] While therapeutic strategies able to change the natural history of the disease are developing, it is of major importance to have available predictive factors for aggressive disease to try and target these therapeutic strategies. Clinical predictors have probably been the most broadly studied. In both Crohn's disease (CD) and ulcerative colitis (UC), age at diagnosis, disease location and smoking habit are currently the strongest predictors of disease course. A younger age at onset is associated with more aggressive disease both in CD and UC. Disease location in CD is associated with different types of complications: surgery and recurrence in upper gastrointestinal and proximal small bowel disease; and surgery in distal small bowel disease and peri-anal lesions in rectal disease. In UC, extensive colitis is clearly been associated with more severe disease. Finally, active smoking globally increases disease severity in CD but decreases it in UC. Besides these important factors, others may predispose to some specific disease evolution and complications, and are also reviewed in the present paper.
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Belaiche, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Reenaers, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Gastro-Entérologie-Hépatologie
Language :
English
Title :
Do clinical factors help to predict disease course in inflammatory bowel disease?
Publication date :
2010
Journal title :
World Journal of Gastroenterology
ISSN :
1007-9327
eISSN :
2219-2840
Publisher :
W J G Press, Beijing, China
Volume :
16
Issue :
21
Pages :
2600-3
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 February 2011

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