Reference : Involvement of placental growth factor in Wallerian degeneration
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Neurology
http://hdl.handle.net/2268/76892
Involvement of placental growth factor in Wallerian degeneration
English
Chaballe, Linda mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Close, Pierre mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
SEMPELS, Maxime [Centre Hospitalier Universitaire de Liège - CHU > > Chirurgie cardio-vasculaire >]
DELSTANCHE, Stéphanie [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
FANIELLE, Julien [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Moons, Lieve [> >]
Carmeliet, Peter [> >]
Schoenen, Jean mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Chariot, Alain mailto [Université de Liège - ULg > Département de pharmacie > Chimie médicale >]
Franzen, Rachelle mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Neuro-anatomie >]
Mar-2011
Glia
Wiley Liss
59
3
379-396
Yes (verified by ORBi)
International
0894-1491
1098-1136
New York
NY
[fr] Dégénération wallérienne ; NF kappaB ; Cellules de Schwann
[en] PNS injury ; inflammation ; Schwann cell ; cytokine ; NF-kB
[en] Wallerian degeneration (WD) is an inflammatory process of nerve degeneration, which occurs more rapidly in the peripheral nervous system compared with the central nervous system, resulting, respectively in successful and aborted axon regeneration. In the peripheral nervous system, Schwann cells (SCs) and macrophages, under the control of a network of cytokines and chemokines, represent the main cell types involved in this process. Within this network, the role of placental growth factor (PlGF) remains totally unknown. However, properties like monocyte activation/attraction, ability to increase expression of pro-inflammatory molecules, as well as neuroprotective effects, make it a candidate likely implicated in this process. Also, nothing is described about the expression and localization of this molecule in the peripheral nervous system. To address these original questions, we decided to study PlGF expression under physiological and degenerative conditions and to explore its role in WD, using a model of sciatic nerve transection in wild-type and Pgf(-/-) mice. Our data show dynamic changes of PlGF expression, from periaxonal in normal nerve to SCs 24h postinjury, in parallel with a p65/NF-κB recruitment on Pgf promoter. After injury, SC proliferation is reduced by 30% in absence of PlGF. Macrophage invasion is significantly delayed in Pgf(-/-) mice compared with wild-type mice, which results in worse functional recovery. MCP-1 and proMMP-9 exhibit a 3-fold reduction of their relative expressions in Pgf(-/-) injured nerves, as demonstrated by cytokine array. In conclusion, this work originally describes PlGF as a novel member of the cytokine network of WD.
Giga-Neurosciences, Giga Signal transduction
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/76892
also: http://hdl.handle.net/2268/101201

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