Article (Scientific journals)
On the Intercostal Muscle Compensation for Diaphragmatic Paralysis in the Dog
Brichant, Jean-François; De Troyer, A.
1997In Journal of Physiology, 500 ((Pt 1)), p. 245-53
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Abstract :
[en] 1. Paralysis of the diaphragm in the dog is known to cause a compensatory increase in activation of the inspiratory intercostal muscles (parasternal intercostals, external intercostals, and levator costae). The present studies were designed to assess the mechanism(s) of that compensation. 2. Complete, selective diaphragmatic paralysis was induced by injecting local anaesthetic into small silicone cuffs placed around the phrenic nerve roots in the neck. 3. Paralysis produced a decrease in tidal volume and an increase in arterial P(CO2) (P(a,CO2)). The increased hypercapnic drive was a primary determinant of the increased inspiratory intercostal activity. 4. However, paralysis also produced an increased inspiratory cranial displacement of the ribs. When this increased rib displacement was reduced to that seen before paralysis, it appeared that the increase in external intercostal and levator costae inspiratory activity was commonly greater than anticipated on the basis of the increased P(a,CO2). 5. Diaphragmatic paralysis after bilateral vagotomy also elicited disproportionate increases in inspiratory intercostal activity, thus indicating that these increases are not caused by vagal afferent inputs. 6. These observations are consistent with the idea that the intercostal muscle compensation for diaphragmatic paralysis is, in part, due to the release of an inhibition originating from the contracting diaphragm. This inhibition might arise in the diaphragmatic tendon organs.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Brichant, Jean-François ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
De Troyer, A.
Language :
English
Title :
On the Intercostal Muscle Compensation for Diaphragmatic Paralysis in the Dog
Publication date :
01 April 1997
Journal title :
Journal of Physiology
ISSN :
0022-3751
eISSN :
1469-7793
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
500
Issue :
(Pt 1)
Pages :
245-53
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 October 2008

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