Article (Scientific journals)
Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mixture during combined lumbar epidural and general anesthesia.
Senard, Marc; Ledoux, Didier; Darmont, Pascaline et al.
1998In Acta Anaesthesiologica Belgica, 49 (3), p. 167-73
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Keywords :
Adolescent; Adrenergic alpha-Agonists/administration & dosage; Adult; Aged; Analgesia, Epidural; Analysis of Variance; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Local/administration & dosage; Blood Pressure/drug effects; Bupivacaine/administration & dosage; Chi-Square Distribution; Clonidine/administration & dosage; Double-Blind Method; Epinephrine/administration & dosage; Female; Heart Rate/drug effects; Humans; Intervertebral Disk/surgery; Lumbar Vertebrae/surgery; Male; Middle Aged; Nerve Block; Prospective Studies
Abstract :
[en] Clonidine or epinephrine are frequently combined to epidural local anesthetics to strengthen sensory block and prolong analgesia. Both drugs impair the hemodynamic profile of central neural blockade but the effects of their combination on arterial pressure and heart rate are not known and were examined in this double-blind prospective randomised study. Forty four patients scheduled for lumbar disc surgery were allocated to two groups. Epidural anesthesia was obtained by administration of 150 micrograms clonidine in 15 ml bupivacaine 0.25% solution without (group C) or with (group C + E) 37.5 micrograms epinephrine. Systolic, mean, diastolic arterial pressure and heart rate were measured throughout the study. Combined epidural and general anesthesia induced a significant decrease in arterial pressure and heart rate in both groups. SAP and MAP decreased significantly less in the patients receiving epinephrine. Low dose epidural epinephrine decreases arterial pressure instability during combined epidural and general anesthesia.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Senard, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Ledoux, Didier  ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
Darmont, Pascaline ;  Centre Hospitalier Universitaire de Liège - CHU > HOSPITALISATION - CHIR. CARDIAQUE (SN +1A)
Hans, Pol ;  Centre Hospitalier Universitaire de Liège - CHU > Anesthésie et réanimation
Brichant, Jean-François ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Bonnet, Fabienne ;  Centre Hospitalier Universitaire de Liège - CHU > Frais généraux et de personnel
Language :
English
Title :
Hemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mixture during combined lumbar epidural and general anesthesia.
Publication date :
1998
Journal title :
Acta Anaesthesiologica Belgica
ISSN :
0001-5164
eISSN :
2736-5239
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
49
Issue :
3
Pages :
167-73
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 October 2008

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