Reference : Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Biotechnology
Human health sciences : Neurology
http://hdl.handle.net/2268/76475
Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms
English
Malgrange, Brigitte mailto [Université de Liège - ULg > > GIGA - Neurosciences - Neurologie >]
Borgs, Laurence mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Grobarczyk, Benjamin [Université de Liège - ULg > Département des sciences cliniques > Neurologie]
Purnelle, Audrey mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Ernst, Patricia mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Moonen, Gustave mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Nguyen, Laurent mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
2011
Cellular and Molecular Life Sciences : CMLS
Birkhäuser
68
4
635-49
Yes (verified by ORBi)
International
1420-682X
1420-9071
Basel
Switzerland
[en] Animals ; Cell Differentiation ; Embryonic Stem Cells/cytology/metabolism/pathology ; iPS ; hES ; Stem cells ; human ; Neurodegenerative Diseases/metabolism/pathology ; Neurons/cytology/metabolism/pathology ; Pluripotent Stem Cells/cytology/metabolism/pathology
[en] Human pluripotent stem cells, including embryonic (hES) and induced pluripotent stem cells (hiPS), retain the ability to self-renew indefinitely, while maintaining the capacity to differentiate into all cell types of the nervous system. While human pluripotent cell-based therapies are unlikely to arise soon, these cells can currently be used as an inexhaustible source of committed neurons to perform high-throughput screening and safety testing of new candidate drugs. Here, we describe critically the available methods and molecular factors that are used to direct the differentiation of hES or hiPS into specific neurons. In addition, we discuss how the availability of patient-specific hiPS offers a unique opportunity to model inheritable neurodegenerative diseases and untangle their pathological mechanisms, or to validate drugs that would prevent the onset or the progression of these neurological disorders.
Giga-Neurosciences
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE
Researchers
http://hdl.handle.net/2268/76475
also: http://hdl.handle.net/2268/95471
10.1007/s00018-010-0557-6

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