ORBi: Malgrange Brigitte - Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms

Reference : Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biotechnology Life sciences : Anatomy (cytology, histology, embryology...) & physiology Human health sciences : Neurology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/76475

Title :	Using human pluripotent stem cells to untangle neurodegenerative disease mechanisms
Language :	English
Author, co-author :	Malgrange, Brigitte [Université de Liège - ULg > > GIGA - Neurosciences - Neurologie >]
	Borgs, Laurence [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
	Grobarczyk, Benjamin [Université de Liège - ULg > Département des sciences cliniques > Neurologie]
	Purnelle, Audrey [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
	Ernst, Patricia [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	Moonen, Gustave [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
	Nguyen, Laurent [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Publication date :	2011
Journal title :	Cellular and Molecular Life Sciences : CMLS
Publisher :	Birkhäuser
Volume :	68
Issue/season :	4
Pages :	635-49
Audience :	International
ISSN :	1420-682X
e-ISSN :	1420-9071
City :	Basel
Country :	Switzerland
Keywords :	[en] Animals ; Cell Differentiation ; Embryonic Stem Cells/cytology/metabolism/pathology ; iPS ; hES ; Stem cells ; human ; Neurodegenerative Diseases/metabolism/pathology ; Neurons/cytology/metabolism/pathology ; Pluripotent Stem Cells/cytology/metabolism/pathology
Abstract :	[en] Human pluripotent stem cells, including embryonic (hES) and induced pluripotent stem cells (hiPS), retain the ability to self-renew indefinitely, while maintaining the capacity to differentiate into all cell types of the nervous system. While human pluripotent cell-based therapies are unlikely to arise soon, these cells can currently be used as an inexhaustible source of committed neurons to perform high-throughput screening and safety testing of new candidate drugs. Here, we describe critically the available methods and molecular factors that are used to direct the differentiation of hES or hiPS into specific neurons. In addition, we discuss how the availability of patient-specific hiPS offers a unique opportunity to model inheritable neurodegenerative diseases and untangle their pathological mechanisms, or to validate drugs that would prevent the onset or the progression of these neurological disorders.
Research units :	Giga-Neurosciences
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/76475
	also: http://hdl.handle.net/2268/95471
DOI :	10.1007/s00018-010-0557-6

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