ORBi: Buchet J. P. - Renal effects of cadmium body burden of the general population

Reference : Renal effects of cadmium body burden of the general population


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Public health, health care sciences & services Human health sciences : Urology & nephrology
	To cite this reference:	http://hdl.handle.net/2268/76428

Title :	Renal effects of cadmium body burden of the general population
Language :	English
Author, co-author :	Buchet, J. P. [Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit > > >]
	Lauwerys, R. [Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit > > >]
	Roels, H. [Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit > > >]
	Bernard, A. [Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit > > >]
	Bruaux, P. [Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology > > >]
	Claeys, F. [Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology > > >]
	Ducoffre, G. [Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology > > >]
	De Plaen, P. [Ministry of Health and Social Affairs, Brusels, Belgium > Institute of Hygiene and Epidemiology > > >]
	Staessen [Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension nd Cardiovascular Rehabilitation Unit > >]
	Amery, A. [Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit > >]
	Lijnen, P. [Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit > >]
	Thijs, L. [Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit > >]
	Rondia, D. [Université de Liège - ULg > Environmental Toxicology Unit > > >]
	Sartor, F. [Université de Liège - ULg > Environmental Toxicology Unit > > >]
	Saint-Remy, Annie [Université de Liège - ULg > Département des sciences cliniques > Néphrologie >]
	Nick, L. [Université de Liège > Environmental Toxicology Unit > > >]
Publication date :	1990
Journal title :	Lancet
Publisher :	Lancet Publishing Group
Volume :	336
Pages :	69-702
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0140-6736
e-ISSN :	1474-547X
City :	London
Country :	United Kingdom
Keywords :	[en] caldmium ; environmental exposure ; renal effects
Abstract :	[en] In a cross-sectional population study to assess whether environmental exposure to cadmium associated with renal dysfunction, 1699 subjects aged 20-80 years were studied as a random sample of four areas of Belgium with varying degrees of cadmium pollution. After standardisation fo several possible confounding factors, five variables (urinary excretion of retinol-binding protein, N-acetyl-ß-glucosaminidase, ß2-microglobulin, aminoacids, and calcium) were significantly associated with the urinary excretion of cadmium (as a marker of cadmium body burden) suggesting the presence of tubular dysfunction. There was a 10% probablility of values of these variables being abnormal when cadmium excretion exceeded 2-4 µg/24h. Excretion reached also evidence that diabetic patients may be more susceptible to the toxic effect of cadmium on the renal proximal tubule.
Target :	Professionals
Permalink :	http://hdl.handle.net/2268/76428

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	File	Commentary	Version	Size	Access
Open access	1990 Lancet 336 699-702.pdf		Publisher postprint	4.19 MB	View/Open

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