Reference : Tumoral and choroidal vascularization: differential cellular mechanisms involving pla...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/76401
Tumoral and choroidal vascularization: differential cellular mechanisms involving plasminogen activator inhibitor type I.
English
Jost, Maud [> > > >]
Maillard, Catherine [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Lecomte, Julie mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
Lambert, Vincent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Tjwa, Marc [> > > >]
Blaise, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Alvarez Gonzalez, Maria-Luz mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Bajou, Khalid mailto [Université de Liège - ULg > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Blacher, Silvia mailto [Université de Liège - ULg > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Motte, Patrick mailto [Université de Liège - ULg > Département des sciences de la vie > Génomique fonctionnelle et imagerie moléculaire végétale >]
Humblet, Chantal mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Defresne, Marie-Paule mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Thiry, Marc mailto [Université de Liège - ULg > Département des sciences de la vie > Biologie cellulaire >]
Frankenne, Francis [> > > >]
Gothot, André mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
Carmeliet, Peter [> > > >]
Rakic, Jean-Marie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Ophtalmologie >]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Noël, Agnès mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme >]
2007
American Journal of Pathology
American Society for Investigative Pathology
171
4
1369-80
Yes (verified by ORBi)
International
0002-9440
1525-2191
Bethesda
MD
[en] Animals ; Bone Marrow Cells/physiology ; Bone Marrow Transplantation ; Carcinoma/blood supply ; Choroidal Neovascularization/etiology/metabolism/pathology ; Keratinocytes/pathology/transplantation ; Mice ; Mice, Transgenic ; Neovascularization, Pathologic/etiology/metabolism/pathology ; Plasminogen Activator Inhibitor 1/genetics/physiology ; Skin Neoplasms/blood supply
[en] An adequate balance between serine proteases and their plasminogen activator inhibitor-1 (PAI-1) is critical for pathological angiogenesis. PAI-1 deficiency in mice is associated with impaired choroidal neovascularization (CNV) and tumoral angiogenesis. In the present work, we demonstrate unexpected differences in the contribution of bone marrow (BM)-derived cells in these two processes regulated by PAI-1. PAI-1(-/-) mice grafted with BM-derived from wild-type mice were able to support laser-induced CNV formation but not skin carcinoma vascularization. Engraftment of irradiated wild-type mice with PAI-1(-/-) BM prevented CNV formation, demonstrating the crucial role of PAI-1 delivered by BM-derived cells. In contrast, the transient infiltration of tumor transplants by local PAI-1-producing host cells rather than by BM cells was sufficient to rescue tumor growth and angiogenesis in PAI-1-deficient mice. These data identify PAI-1 as a molecular determinant of a local permissive soil for tumor angiogenesis. Altogether, the present study demonstrates that different cellular mechanisms contribute to PAI-1-regulated tumoral and CNV. PAI-1 contributes to BM-dependent choroidal vascularization and to BM-independent tumor growth and angiogenesis.
http://hdl.handle.net/2268/76401
also: http://hdl.handle.net/2268/14231
10.2353/ajpath.2007.070074

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