ORBi: Saegerman Claude - Decision support tools for clinical diagnosis of disease in cows with suspected bovine spongiform encephalopathy.

Reference : Decision support tools for clinical diagnosis of disease in cows with suspected bovine s...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Microbiology Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/7637

Title :	Decision support tools for clinical diagnosis of disease in cows with suspected bovine spongiform encephalopathy.
Language :	English
Author, co-author :	Saegerman, Claude [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér. >]
	Speybroeck, N. [> > > >]
	Roels, S. [> > > >]
	Vanopdenbosch, E. [> > > >]
	Thiry, Etienne [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
	Berkvens, D. [> > > >]
Publication date :	2004
Journal title :	Journal of Clinical Microbiology
Publisher :	American Society for Microbiology (ASM)
Volume :	42
Issue/season :	1
Pages :	172-8
Audience :	International
ISSN :	0095-1137
e-ISSN :	1098-660X
City :	Washington
Country :	DC
Keywords :	[en] Animals ; Cattle ; Decision Support Systems, Clinical ; Decision Trees ; Encephalopathy, Bovine Spongiform/diagnosis/pathology ; Female ; Time Factors
Abstract :	[en] Reporting of clinically suspected cattle is currently the most common method for detecting cases of bovine spongiform encephalopathy (BSE). Improvement of clinical diagnosis and decision-making remains crucial. A comparison of clinical patterns, consisting of 25 signs, was made between all 30 BSE cases, confirmed in Belgium before October 2002, and 272 suspected cases that were subsequently determined to be histologically, immunohistochemically, and scrapie-associated-fiber negative. Seasonality in reporting suspected cases was observed, with more cases being reported during wintertime when animals were kept indoors. The median duration of illness was 30 days. The 10 most relevant signs of BSE were kicking in the milking parlor, hypersensitivity to touch and/or sound, head shyness, panic-stricken response, reluctance to enter in the milking parlor, abnormal ear movement or carriage, increased alertness behavior, reduced milk yield, teeth grinding, and temperament change. Ataxia did not appear to be a specific sign of BSE. A classification and regression tree was constructed by using the following four features: age of the animal, year of birth, number of relevant BSE signs noted, and number of clinical signs, typical for listeriosis, noted. The model had a sensitivity of 100% and a specificity of 85%. This approach allows the use of an interactive decision-support tool, based entirely on odds ratios, a statistic independent of disease prevalence.
Permalink :	http://hdl.handle.net/2268/7637

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