Reference : Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case ...
Scientific journals : Article
Human health sciences : Hematology
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Oncology
http://hdl.handle.net/2268/76204
Primary mucosa-associated lymphoid tissue lymphoma of the gallbladder: report of a case harboring API2/MALT1 gene fusion.
English
Bisig, Bettina mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Copie-Bergman, Christiane [> > > >]
Baia, Maryse [> > > >]
Gaulard, Philippe [> > > >]
Delbecque, Katty mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Fassotte, Marie-France mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Boniver, Jacques mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
de Leval, Laurence mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques - Département des sciences biomédicales et précliniques >]
2009
Human Pathology
W.B. Saunders
40
10
1504-9
Yes (verified by ORBi)
International
0046-8177
1532-8392
Philadelphia
PA
[en] MALT ; Lymphoma ; FISH ; Gallbladder ; Translocation ; Chromosome ; API2 ; MALT1 ; Fusion ; Oncogene
[en] The genetic alterations underlying extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue type are heterogeneous and show variation according to the tumor site. Here, we report a case of mucosa-associated lymphoid tissue lymphoma of the gallbladder with genetic characterization. This lymphoma, diagnosed in a 75-year-old woman who underwent cholecystectomy for suspected acute cholecystitis, presented as diffuse thickening of the gallbladder wall. The morphology was typical of mucosa-associated lymphoid tissue lymphoma, and by immunophenotype, the tumor cells were CD20+ CD5- CD10- CD23- CD43- BCL6- BCL2+ IgM+ IgD- lambda+, with moderate nuclear expression of BCL10. Interphase fluorescence in situ hybridization analysis on paraffin sections, using a fusion probe for API2/MALT1, demonstrated 2 fusion signals in most nuclei, bringing the first documentation of a t(11;18)(q21;q21) in this exceptional primary disease location.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/76204
10.1016/j.humpath.2009.02.018

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