Article (Scientific journals)
Antibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa
Dewals, Benjamin G; Gillet, Laurent; Gerdes, Truuske et al.
2005In Veterinary Microbiology, 110 (3-4), p. 209-220
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Keywords :
bovine herpesvirus 4; African buffalo; seroprevalence of anti-BoHV-4 antibodies; Buffaloes/immunology/virology; Cell Line; Herpesviridae Infections/blood/epidemiology/immunology/veterinary; Kenya/epidemiology; Rhadinovirus/immunology/isolation & purification; Seroepidemiologic Studies; South Africa/epidemiology; Tanzania/epidemiology; Tumor Virus Infections/blood/epidemiology/immunology/veterinary; Uganda/epidemiology
Abstract :
[en] Bovine herpesvirus 4 (BoHV-4) has been isolated from cattle throughout the world. Interestingly, a survey of wild African buffaloes mainly from the Maasai Mara Game Reserve in Kenya revealed that 94% of the animals tested had anti-BoHV-4 antibodies [Rossiter, P.B., Gumm, I.D., Stagg, D.A., Conrad, PA., Mukolwe, S., Davies, F.G., White, H., 1989. Isolation of bovine herpesvirus-3 from African buffaloes (Syncerus caffer). Res. Vet. Sci. 46, 337-343]. These authors also proposed that the serological antigenic relationship existing between BoHV-4 and alcelaphine herpesvirus I (A1HV-1) could confer to BoHV-4 infected buffaloes a protective immune response against lethal A1HV-1 infection. In the present study, we addressed two questions related to Rossiter et al. paper. Firstly, to investigate the role of the African buffalo as a natural host species of BoHV-4, the seroprevalence of anti-BoHV-4 antibodies was analysed in wild African buffaloes throughout eastern and southern Africa. A total of 400 sera was analysed using two complementary immunofluorescent assays. These analyses revealed that independently of their geographical origin, wild African buffaloes exhibit a seroprevalence of anti-BoHV-4 antibodies higher than 68%. This result is by far above the seroprevalence generally observed in cattle. Our data are discussed in the light of our recent phylogenetic study demonstrating that the BoHV-4 Bo17 gene has been acquired from a recent ancestor of the African buffalo. Secondly, we investigated the humoral antigenic relationship existing between BoHV-4 and A1HV-1. Our results demonstrate that among the antigens expressed in A1HV-1 infected cells, epitope(s) recognised by anti-BoHV-4 antibodies are exclusively nuclear, suggesting that the putative property of BoHV-4 to confer an immune protection against A1HV-1 relies on a cellular rather than on a humoral immune response. (c) 2005 Elsevier B.V. All rights reserved.
Disciplines :
Microbiology
Veterinary medicine & animal health
Author, co-author :
Dewals, Benjamin G  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Gillet, Laurent  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Gerdes, Truuske
Taracha, Evans L. N.
Thiry, Etienne ;  Université de Liège - ULiège > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales
Vanderplasschen, Alain ;  Université de Liège - ULiège > Immunologie et vaccinologie
Language :
English
Title :
Antibodies against bovine herpesvirus 4 are highly prevalent in wild African buffaloes throughout eastern and southern Africa
Publication date :
2005
Journal title :
Veterinary Microbiology
ISSN :
0378-1135
eISSN :
1873-2542
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
110
Issue :
3-4
Pages :
209-220
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 November 2010

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