Poster (Scientific congresses and symposiums)
Towards the synthesis of mannose derivatives of natural phenolic compounds
Sainvitu, Pauline; Nott, Katherine; Richard, Gaetan et al.
2010Journée scientifique annuelle de la Société royale de Chimie - Chimie verte
 

Files


Full Text
Towards the synthesis of mannose derivatives of phenolics antioxidant.pdf
Author postprint (535.69 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
mannose; enzymatic synthesis; beta glucosidase
Abstract :
[en] The aim of this project is to graft a sugar moiety onto polyfunctional natural phenolic compounds. This should enhance their water solubility. The choice of an adequate sugar such as mannose could provide cellular recognition. The synthesis route was first tested on cinnamyl alcohol which is structurally close to the base pattern of natural phenolic compounds. <br />Two compounds are tested to catalyse the glycosilation between cinnamyl alcohol and D-mannose. The first one is an enzyme, the -glucosidase from almond, and the second one is a mineral acid catalyst immobilized on silica. Results show that -glucosidase is able to synthetize cinnamyl mannoside from mannose and cinnamyl alcohol. Furthermore, enzyme-catalyzed route lead to only one product and is so more specific than the chemical route where several products are observed. The obtaining of one product with a unique structure is interesting for the fundamental study of structure-function relationships (Interaction of the product with model membranes by Isothermal Titration Calorymetry and with the Langmuir Trough technique). In a future work, the reaction will be tested with more complex molecules (for example coniferyl alcohol).
Research center :
Unité de Chimie Biologique Industrielle
Disciplines :
Chemistry
Agriculture & agronomy
Author, co-author :
Sainvitu, Pauline ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Nott, Katherine ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Richard, Gaetan ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Blecker, Christophe ;  Université de Liège - ULiège > Chimie et bio-industries > Technologie des industries agro-alimentaires
Jérôme, Christine  ;  Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Wathelet, Jean-Paul ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie générale et organique
Paquot, Michel ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Deleu, Magali  ;  Université de Liège - ULiège > Chimie et bio-industries > Chimie biologique industrielle
Language :
English
Title :
Towards the synthesis of mannose derivatives of natural phenolic compounds
Alternative titles :
[fr] Vers la synthèse de dérivés mannosidiques de composés phenoliques naturels
Publication date :
14 October 2010
Number of pages :
A0
Event name :
Journée scientifique annuelle de la Société royale de Chimie - Chimie verte
Event organizer :
Société Royale de Chimie
Event place :
Gembloux, Belgium
Event date :
14 octobre 2010
Name of the research project :
Synthèses enzymatiques appliquées aux produits issus de la biomasse végétale
Funders :
FWB - Fédération Wallonie-Bruxelles [BE]
Available on ORBi :
since 20 November 2010

Statistics


Number of views
91 (26 by ULiège)
Number of downloads
115 (8 by ULiège)

Bibliography


Similar publications



Contact ORBi