Reference : Characterization of caprine herpesvirus 1 glycoprotein D gene and its translation product
Scientific journals : Article
Life sciences : Microbiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/7611
Characterization of caprine herpesvirus 1 glycoprotein D gene and its translation product
English
Keuser, Véronique [> > > >]
Detry, Bruno [ > > ]
Thiry, Julien mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
de Fays, K. [> > > >]
Schynts, F. [> > > >]
Pastoret, Paul-Pierre mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Département des maladies infectieuses et parasitaires >]
Vanderplasschen, Alain mailto [Université de Liège - ULg > > Immunologie et vaccinologie >]
Thiry, Etienne mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
Feb-2006
Virus Research
Elsevier Science Bv
115
2
112-121
Yes (verified by ORBi)
International
0168-1702
Amsterdam
[en] alphaherpesvirus ; caprine ; bovine ; glycoprotein D
[en] Caprine herpesvirus 1 (CpHV- 1) is responsible of systemic infection in neonatal kids as well as abortion and fertility disorders in adult goats. This virus is closely related to bovine herpesvirus 1 (BoHV-1) which causes infectious bovine rhinotracheitis. Glycoprotein D (gD) mediates important functions in alphaherpesviruses and is also a main inummogen. The sequence of CpHV-1 gD gene and the biochemical properties of its translation product were analyzed and compared to those of BoHV-1 and other alphaherpesviruses. A relatively high homology was found between CpHV-1 and BoHV-1 glycoproteins D amino acid sequences (similarity of 68.8%). Moreover, six cysteine residues are conserved by CpHV-1 gD and the other studied alphaherpesviruses. CpHV-1 gD has a molecular mass similar to BoHV-1 gD and contains complex N-linked oligosaccharides. In contrast to the BoHV-1 gD, CpHV-1 gD is expressed as a late protein. In spite of the observed differences which could influence its biological functions, CpHV-1 gD, shares most characteristics with other alphaherpesviruses and especially BoHV-1. (c) 2005 Elsevier B.V. All rights reserved.
http://hdl.handle.net/2268/7611
10.1016/j.virusres.2005.07.009

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