ORBi: Thiry Julien - A live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine induces a partial cross-protection against caprine herpesvirus 1 infection in goats

Reference : A live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine induces a partial...


	Document type :	Scientific congresses and symposiums : Paper published in a journal
	Discipline(s) :	Life sciences : Veterinary medicine & animal health Life sciences : Microbiology
	To cite this reference:	http://hdl.handle.net/2268/7609

Title :	A live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine induces a partial cross-protection against caprine herpesvirus 1 infection in goats
Language :	English
Author, co-author :	Thiry, Julien [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
	Tempesta, M. [> > > >]
	Camero, M. [> > > >]
	Tarsitano, E. [> > > >]
	Bellacicco, A. L. [> > > >]
	Thiry, Etienne [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
	Buonavoglia, C. [> > > >]
Publication date :	31-Mar-2006
Journal title :	Veterinary Microbiology
Publisher :	Elsevier Science Bv
Volume :	113
Issue/season :	3-4
Pages :	303-308
Audience :	International
ISSN :	0378-1135
City :	Amsterdam
Event name :	Proceedings of the 2nd ESVV Veterinary Herpesvirus Symposium
Event date :	02-04 March 2005
Event place (city) :	Ghent
Event country :	Belgium
Keywords :	[en] herpesvirus ; bovine ; caprine ; glycoprotein E ; vaccine
Abstract :	[en] Taking into account the close antigenic relationship between bovine herpesvirus 1 (BoHV-1) and caprine herpesvirus 1 (CpHV-1), a live attenuated glycoprotein E (gE) negative BoHV-1 vaccine was assessed in goats with the aim to protect against CpHV-1 infection. Vaccine safety was evaluated by intranasal inoculation of two groups of goats with either a gE-negative BoHV-1 vaccine or a virulent BoHV-1. The length of viral excretion and the peak viral titre were reduced with the gE-negative vaccine. To assess the efficacy, two goats were inoculated intranasally twice 2 weeks apart with a gE-negative BoHV-1 vaccine. Four weeks later, immunised and control goats were challenged with CpHV-1. A 2 log(10) reduction in the peak viral titre was observed and the challenge virus excretion lasted 2 days more in immunised than in control goats. These data indicate the safety and the partial efficacy of a live attenuated gE-negative BoHV-1 vaccine intranasally administrated in goats. (c) 2005 Elsevier B.V. All rights reserved.
Permalink :	http://hdl.handle.net/2268/7609
DOI :	10.1016/j.vetmic.2005.11.001

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