Reference : A live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine induces a partial...
Scientific congresses and symposiums : Paper published in a journal
Life sciences : Microbiology
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/7609
A live attenuated glycoprotein E negative bovine herpesvirus 1 vaccine induces a partial cross-protection against caprine herpesvirus 1 infection in goats
English
Thiry, Julien mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
Tempesta, M. [> > > >]
Camero, M. [> > > >]
Tarsitano, E. [> > > >]
Bellacicco, A. L. [> > > >]
Thiry, Etienne mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
Buonavoglia, C. [> > > >]
31-Mar-2006
Veterinary Microbiology
Elsevier Science Bv
113
3-4
303-308
Yes (verified by ORBi)
International
0378-1135
Amsterdam
Proceedings of the 2nd ESVV Veterinary Herpesvirus Symposium
02-04 March 2005
Ghent
Belgium
[en] herpesvirus ; bovine ; caprine ; glycoprotein E ; vaccine
[en] Taking into account the close antigenic relationship between bovine herpesvirus 1 (BoHV-1) and caprine herpesvirus 1 (CpHV-1), a live attenuated glycoprotein E (gE) negative BoHV-1 vaccine was assessed in goats with the aim to protect against CpHV-1 infection. Vaccine safety was evaluated by intranasal inoculation of two groups of goats with either a gE-negative BoHV-1 vaccine or a virulent BoHV-1. The length of viral excretion and the peak viral titre were reduced with the gE-negative vaccine. To assess the efficacy, two goats were inoculated intranasally twice 2 weeks apart with a gE-negative BoHV-1 vaccine. Four weeks later, immunised and control goats were challenged with CpHV-1. A 2 log(10) reduction in the peak viral titre was observed and the challenge virus excretion lasted 2 days more in immunised than in control goats. These data indicate the safety and the partial efficacy of a live attenuated gE-negative BoHV-1 vaccine intranasally administrated in goats. (c) 2005 Elsevier B.V. All rights reserved.
http://hdl.handle.net/2268/7609
10.1016/j.vetmic.2005.11.001

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