Reference : Comparison of the amnesic, ataxic and hypothermic effects of ethanol and acetaldehyde in...
Scientific congresses and symposiums : Paper published in a journal
Social & behavioral sciences, psychology : Animal psychology, ethology & psychobiology
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/76082
Comparison of the amnesic, ataxic and hypothermic effects of ethanol and acetaldehyde in mice
English
Closon, Catherine mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
Quertemont, Etienne mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
2010
Alcoholism, Clinical & Experimental Research
Blackwell Publishing
34
8
92A-92A
No
No
International
0145-6008
1530-0277
Oxford
United Kingdom
15th World Congress of the International Society for Biomedical Research on Alcoholism
13-16 septembre 2010
International Society for Biomedical Research on Alcoholism (ISBRA)
Paris
France
[en] Acetaldehyde ; Ethanol ; Hypothermia ; Mice ; Amnesia ; Ataxia
[en] Acetaldehyde, the first metabolite of ethanol, has been suggested to be involved in many behavioral effects of ethanol. However, very few studies have been published on the role of acetaldehyde in the amnesic and ataxic effects of ethanol. The aim of the present studies was to compare the profiles of ethanol and acetaldehyde in several behavioral tests, measuring motor coordination, learning and memory in mice. Female Swiss mice were injected intraperitoneally with ethanol (0-3g/kg) and acetaldehyde (100-300mg/kg). The effects of these substances on a series of representative behaviors were investigated. The amnesic effects were tested with an object recognition task and a one-trial passive avoidance test. Additionally, the rectal temperatures were used to evaluate the hypothermic effects of the two substances. Finally, motor coordination was assessed using the accelerating rotarod test. The results showed that acetaldehyde, like ethanol, altered memory as shown by a reduced performance in the passive avoidance test and the object recognition task. In addition, acetaldehyde at doses between 100 and 300 mg/kg induced significant hypothermic effects, but that was of shorter duration than ethanol-induced hypothermia. Finally, significant ataxic effects of both acetaldehyde and ethanol were observed in the accelerating rotarod test. Overall, the results of the present study clearly show that acetaldehyde, like ethanol, has amnesic, hypothermic and ataxic properties in mice at least at relatively high concentrations.
Centre de Neurosciences Cognitives et Comportementales
Researchers ; Professionals
http://hdl.handle.net/2268/76082

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Abstract ISBRA 2010 Closon.pdfAuthor preprint10.16 kBView/Open
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