Article (Scientific journals)
In situ characterization in freeze-fractured mouse thymuses of lymphoepithelial complexes ultrastructurally similar to isolated thymic nurse cells.
Defresne, Marie-Paule; Goffinet, Gerhard; Boniver, Jacques
1986In Tissue and Cell, 18 (3), p. 321-30
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Keywords :
Animals; Epithelial Cells; Epithelium/ultrastructure; Freeze Fracturing; Lymphocytes/cytology/ultrastructure; Mice; Mice, Inbred C57BL; Microscopy, Electron; Microscopy, Electron, Scanning; Thymus Gland/cytology/ultrastructure
Abstract :
[en] Scanning and transmission electron microscopy of the cracked surfaces of cryofractured pre-fixed C57BL/Ka mouse thymus reveals the existence of cell complexes, distinct from the surrounding cell organization, in which groups of lymphocytes are delimited by large cytoplasmic sheets or envelopes. These complexes, located in the subcapsular and cortical regions, display morphological features similar to that of the thymic nurse cells (TNCs), which can be isolated from the mouse or human thymus enzymatically dissociated. They can be considered as dynamic systems able to modify their three-dimensional organization, namely with regard to intrathymic cellular traffic involved in T-lymphocyte maturation.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences précliniques MI > Anatomie et cytologie pathologiques
Goffinet, Gerhard ;  Université de Liège - ULiège > > Section zoologie (biologie animale)
Boniver, Jacques ;  Centre Hospitalier Universitaire de Liège - CHU > Anatomie pathologique
Language :
English
Title :
In situ characterization in freeze-fractured mouse thymuses of lymphoepithelial complexes ultrastructurally similar to isolated thymic nurse cells.
Publication date :
1986
Journal title :
Tissue and Cell
ISSN :
0040-8166
Publisher :
Churchill Livingstone, Inc., Edinburgh, United Kingdom
Volume :
18
Issue :
3
Pages :
321-30
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
FRSM - Fonds de la Recherche Scientifique Médicale [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
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