Reference : Maintenance of functional human cancellous bone and human hematopoiesis in NOD/SCID mice
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/75948
Maintenance of functional human cancellous bone and human hematopoiesis in NOD/SCID mice
English
Hubin, F. [> > > >]
Humblet, Chantal mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Belaid, Zakia [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Greimers, Roland mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques >]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Thiry, Albert mailto [Université de Liège - ULg > > Anatomie pathologique >]
Defresne, Marie-Paule mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
2004
Cell Transplantation
Cognizant Communication Corp
13
7-8
823-831
Yes (verified by ORBi)
International
0963-6897
Elmsford
[en] hematopoiesis ; human bone fragment ; NOD/SCID mice ; in vivo model
[en] Attempts were made to establish models to study interactions between marrow stromal cells and hematopoietic cells in vivo. The approach was to create a NOD-SCID-hu murine model of long-term human hematopoiesis by implantation of a human adult bone fragment. Nine to 12 weeks posuransplantation, human CD45(+) cells were detected in the blood and the spleen of some mice. The histology of the human transplant showed that human bone fragment was viable at 9 weeks. Moreover, vessels of human origin, as assessed by immunohistochemical detection of human beta(2)-microglobulin, were observed in the mouse tissue surrounding the transplanted human fragment.
http://hdl.handle.net/2268/75948

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