Article (Scientific journals)
Maintenance of functional human cancellous bone and human hematopoiesis in NOD/SCID mice
Hubin, F.; Humblet, Chantal; Belaid, Zakia et al.
2004In Cell Transplantation, 13 (7-8), p. 823-831
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Keywords :
hematopoiesis; human bone fragment; NOD/SCID mice; in vivo model
Abstract :
[en] Attempts were made to establish models to study interactions between marrow stromal cells and hematopoietic cells in vivo. The approach was to create a NOD-SCID-hu murine model of long-term human hematopoiesis by implantation of a human adult bone fragment. Nine to 12 weeks posuransplantation, human CD45(+) cells were detected in the blood and the spleen of some mice. The histology of the human transplant showed that human bone fragment was viable at 9 weeks. Moreover, vessels of human origin, as assessed by immunohistochemical detection of human beta(2)-microglobulin, were observed in the mouse tissue surrounding the transplanted human fragment.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Hubin, F.
Humblet, Chantal ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Belaid, Zakia ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Greimers, Roland ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Thiry, Albert ;  Université de Liège - ULiège > Anatomie pathologique
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
English
Title :
Maintenance of functional human cancellous bone and human hematopoiesis in NOD/SCID mice
Publication date :
2004
Journal title :
Cell Transplantation
ISSN :
0963-6897
eISSN :
1555-3892
Publisher :
Cognizant Communication Corp
Volume :
13
Issue :
7-8
Pages :
823-831
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 November 2010

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