Reference : Marker vaccines and the impact of their use on diagnosis and prophylactic measures
Scientific journals : Letter to the editor
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/7584
Marker vaccines and the impact of their use on diagnosis and prophylactic measures
English
Vannier, P. [> > > >]
Capua, I. [> > > >]
Le Potier, M. F. [> > > >]
Mackay, D. K. J. [> > > >]
Muylkens, Benoît mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
Parida, S. [> > > >]
Paton, D. J. [> > > >]
Thiry, Etienne mailto [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Virologie, épidémiologie et pathologie des maladies virales >]
Aug-2007
Revue Scientifique et Technique-Office International des Epizooties
Office Int Epizooties
26
2
351-372
Yes (verified by ORBi)
International
0253-1933
Paris
[en] Aujeszky's disease ; Avian influenza ; classical swine fever ; companion diagnostic tool ; control ; DIVA (Differentiating infected from vaccinated animals) strategy eradication ; foot and mouth disease ; latent infection ; marker vaccine ; sanitary ; measure ; vaccination ; viral excretion ; virus carrier state
[en] Molecular biology and technical advances in DNA recombination have ushered in a new era in vaccinology. This article examines the recent development of specific marker vaccines and examines the impact of their use on the diagnosis and prevention of major infectious diseases. Gene-deleted vaccines, DIVA strategies (differentiating infected from vaccinated animals) and similar methods have been successfully applied in the control and eradication of Aujeszky's disease, infectious bovine rhinotracheitis, classical swine fever, foot and mouth disease and, recently, avian influenza. The efficacy and performance of existing marker vaccines and their companion diagnostic tools (which should be assesed by an independent body) are discussed, as are the ways in which these tools are deployed by competent authorities. The limits and the advantages of the use of marker vaccines are carefully analysed in the light of practical experiences. Although these vaccines can limit the speed and the extent of virus dissemination and thus reduce the number of animals slaughtered, marker vaccines are no substitute for sanitary measures. Early detection and warning systems and the quick implementation of sanitary measures, including stamping out, remain key issues in the control of highly contagious diseases.
http://hdl.handle.net/2268/7584

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