ORBi: Humblet Marie-France - Relationship between haptoglobin, serum amyloid A, and clinical status in a survey of dairy herds during a 6-month period

Reference : Relationship between haptoglobin, serum amyloid A, and clinical status in a survey of da...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health
	To cite this reference:	http://hdl.handle.net/2268/75803

Title :	Relationship between haptoglobin, serum amyloid A, and clinical status in a survey of dairy herds during a 6-month period
Language :	English
Alternative title :	[fr] Relations entre l'haptoglobine, le serum amyloid A et le statut clinique dans une étude sur des troupeaux laitiers durant une période de 6 mois
Author, co-author :	Humblet, Marie-France [Université de Liège - ULg > Département des maladies infectieuses et parasitaires > Epidémiologie et analyse des risques appl. aux sc. vétér. >]
	Guyot, Hugues [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs >]
	Boudry, Benjamin [ > > ]
	Mbayahi, Faustin [ > > ]
	Hanzen, Christian [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Thériogenologie des animaux de production >]
	Rollin, Frédéric [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Médecine interne des équidés, des ruminants et des porcs >]
	Godeau, Jean-Marie [Université de Liège - ULg > Département de sciences fonctionnelles > Département de sciences fonctionnelles >]
Publication date :	2006
Journal title :	Veterinary Clinical Pathology
Publisher :	American Society for Veterinary Clinical Pathology
Volume :	35
Issue/season :	2
Pages :	188-193
Audience :	International
ISSN :	0275-6382
City :	Baton Rouge
Country :	LA
Keywords :	[en] Acute phase proteins ; cattle ; haptoglobin ; serum amyloid A ; dairy
Abstract :	[en] Haptoglobin and serum amyloid A are major acute phase proteins in cattle. Dairy cattle often develop pathologic conditions in the peripartum period; acute phase proteins may be useful in their diagnosis. Objectives: The purpose of this study was to compare the accuracy of serum haptoglobin (Hp) and serum amyloid A (SAA) concentrations with clinical health status for diagnosing disease during the peripartum period in dairy cattle. Methods: Dairy cows from 4 herds were evaluated every 15 days over a 6-month period. Health status was determined by thorough clinical examination. Haptoglobin and SAA concentrations were measured in serum using validated methods and the results were classifed as positive or negative based on defined cutoff points. Disease prevalence, sensitivity, and specificity were compared using clinical examination as the gold standard. Results: A total of 1896 samples from 158 cows were analyzed. Significant increases in mean Hp and SAA concentrations were observed in the week following parturition in both primiparous and multiparous cows, although high interindividual variability was observed. Both Hp and SAA had low sensitivity but higher specificity in determining disease status compared with clinical examination. Increased concentrations of Hp and SAAwere found in ,10% of samples from clinically healthy cows, except in the week after parturition. Conclusions: Haptoglobin and serum amyloid A should be used with caution as markers of inflammation in the week after calving. Poor sensitivity in other postpartum periods could be related to the higher incidence of chronic (vs acute) inflammation. Haptoglobin may be appropriate for routine screening, but further work needs to be done to assess its value as an indicator of herd health.
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/75803

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