Article (Scientific journals)
Effects of exposure to cadmium on calcium metabolism : a population study
Staessen, Jan; Amery, Antoon; Bernard, Alfred et al.
1991In British Journal of Industrial Medicine, 48, p. 710-714
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Keywords :
Exposure; cadmium; calcium metabolism
Abstract :
[en] The objective was to investigate the hypothesis that environmental exposure to cadmium may affect calcium metabolism in the population at large. The 1987 participants (965 men and 1022 women), from 20 to 80 years old, constituted a random sample of the population of four Belgian districts. The urinary excretion of cadmium, a mesure of lifetime exposure, averaged 9.3 nmo/24h in men (range 0.4-324 nmol/24h) and 7.1 nmol/24h (range 0.1-71 nmol/24h) in women. Serum alkaline phosphatase activity and the urinary excretion of calcium correlated significantly and positively with urinary cadmium excretion in both men and women, and serum total calcium concentration negatively with urinary cadmium excretion in men only. The regression coefficients obtained after adjustment for significant covariates indicated that when urinary cadmium excretion increased twofold, serum alkaline phosphatase activity and urinary calcim excretion rose by 3-4% and 0.25 mmol/24h respectively, whereas in men serum total calcium concentration fell by 6 µmol/l. After adjustment for significant covariates the relation between serum total calcium concentration and urinary cadmium excretion was not significant in women. The findings suggest that even at environmental exposure levels calcium metabolism is gadually affected, as cadmium accumulates in the body. The morbidity associated with this phenomenon in industrialised countries remains presently unknown and requires further investigation.
Disciplines :
Public health, health care sciences & services
Urology & nephrology
Author, co-author :
Staessen, Jan;  Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehablitation Unit
Amery, Antoon;  Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehablitation Unit
Bernard, Alfred;  Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Bruaux, Pierre;  Ministry of Health and Socials Affairs, Brussels, Belgium > Institute of Hygiene and Epidemiology
Buchet, Jean-Pierre;  Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Claeys, Françoise;  Ministry of Health and Socials Affairs, Brussels, Belgium > Institute of Hygiene and Epidemiology
De Plaen, Pierre;  Ministry of Health and Socials Affairs, Brussels, Belgium > Institute of Hygiene and Epidemiology
Ducoffre, Geneviève;  Ministry of Health and Socials Affairs, Brussels, Belgium > Institute of Hygiene and Epidemiology
Fagard, Robert;  Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehablitation Unit
Lauwerys, Robert R;  Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Lijnen, Paul;  Katholieke Universiteit Leuven - KUL > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
Nick, Laurence;  Ministry of Health and Socials Affairs, Brussels, Belgium > Institute of Hygiene and Epidemiology
Saint-Remy, Annie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Roels, Harry;  Université Catholique de Louvain - UCL > Industrial Toxicology and Occupational Medicine Unit
Rondia, Désiré;  Université de Liège - ULiège > Environmental Toxicology Unit
Sartor, Francis;  Université de Liège - ULiège > Environmental Toxicology Unit
Thijs, Lutgade;  kul > Pathophysiology > Hypertension and Cardiovascular Rehabilitation Unit
More authors (7 more) Less
Language :
English
Title :
Effects of exposure to cadmium on calcium metabolism : a population study
Publication date :
1991
Journal title :
British Journal of Industrial Medicine
ISSN :
0007-1072
Publisher :
BMJ Group
Volume :
48
Pages :
710-714
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 November 2010

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