ORBi: Grogna Mathurin - Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties

Reference : Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design,...


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry Engineering, computing & technology : Materials science & engineering
	To cite this reference:	http://hdl.handle.net/2268/75752

Title :	Polymer micelles decorated by gadolinium complexes as MRI blood contrast agents: design, synthesis and properties
Language :	English
Author, co-author :	Grogna, Mathurin [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Cloots, Rudi [University of Liège (ULg) > Department of Chemistry > Laboratory of Structural Inorganic Chemistry > >]
	Luxen, André [University of Liège (ULg) > Department of Chemistry > Cyclotron Research Center > >]
	Jérôme, Christine [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
	Passirani, Catherine [INSERM, U 646, Angers, France > > > >]
	Lautram, Nolwenn [INSERM, U 646, Angers, France > > > >]
	Desreux, Jean-François [University of Liège (ULg) > Department of Chemistry > Laboratory of Coordination and Radiochemistry > >]
	Detrembleur, Christophe [University of Liège (ULg) > Department of Chemistry > Center for Education and Research on Macromolecules (CERM) > >]
Publication date :	Sep-2010
Journal title :	Polymer Chemistry
Publisher :	The Royal Society of Chemistry
Volume :	1
Pages :	1485-1490
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	1759-9954
Keywords :	[en] self-assembly in solution ; micelle ; Nuclear Magnetic Resonance Imaging (MRI) contrast agent
Abstract :	[en] New micellar macrocontrast agents with improved contrast at high frequencies were designed by grafting a gadolinium based contrast agent onto functional stealth micelles formed by poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) in water. As evidenced by relaxometry measurements and the hemolytic CH50 test, the new contrast agents are of interest as MRI blood pool agents.
Research units :	Center for Education and Research on Macromolecules (CERM)
Funders :	Politique Scientifique Fédérale (Belgique) = Belgian Federal Science Policy ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; The "IISN"
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/75752
DOI :	10.1039/C0PY00117A
Other URL :	http://pubs.rsc.org/en/Content/ArticlePDF/2010/PY/C0PY00117A/2010-08-06?page=Search

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