Article (Scientific journals)
Association of a new c-Cbl related protein with the very first stages of apoptosis induction
Corsois, L.; Quatannens, B.; Dumont, P. et al.
2002In Cancer Detection and Prevention, 26 (2), p. 93-104
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Keywords :
CARP 90; hydrocortisone; gamma-irradiation; anti-CD3 monoclonal antibody; thymus
Abstract :
[en] This study investigates the involvement of the c-cbl proto-oncogene during the first stages of the apoptotic process. We have already shown that a c-Cbl aptotosis-related protein of 90 kDa (CARP 90) is detected very rapidly in the cytoplasm as well as in the nucleus of murine thymocytes after hydrocortisone (HC) treatment. We report here that this protein appeared as well after in vivo treatment of mice by gamma-irradiation or injection of anti-CD3 monoclonal antibody, two potent thymic apoptosis inductors, providing a close relationship between the occurrence of apoptosis and the appearance of CARP 90. We showed that CARP 90 and p120(cbl) share numerous epitopes strikingly suggesting that CARP 90 is coded by c-cbl. In addition, KO mice do not sustain CARP 90 appearance. We finally showed that CARP 90 contains N- and C-terminal end epitopes of p120(cbl) which suggests that CARP 90 is an alternative spliced form of c-cbl. This protein was also observed under gamma-irradiation in tissues of different origin, which enlarges the physiological significance of this phenomenon. The very rapid CARP 90 appearance under apoptotic conditions in the nucleus of cells originating in different tissues makes this protein if not a possible new actor of the apoptotic process, at least an interesting marker of this process. (C) 2002 International Society for Preventive Oncology. Published by Elsevier Science Ltd. All rights reserved.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Corsois, L.
Quatannens, B.
Dumont, P.
Aumercier, M.
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Regnier, D. C. L.
Language :
English
Title :
Association of a new c-Cbl related protein with the very first stages of apoptosis induction
Publication date :
2002
Journal title :
Cancer Detection and Prevention
ISSN :
0361-090X
eISSN :
1525-1500
Publisher :
Elsevier Sci Ltd, Oxford, United Kingdom
Volume :
26
Issue :
2
Pages :
93-104
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 November 2010

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