Reference : In Vivo Expression of Interleukin-1 Beta (Il-1 Beta), Il-2, Il-4, Il-6, Tumour Necros...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/75657
In Vivo Expression of Interleukin-1 Beta (Il-1 Beta), Il-2, Il-4, Il-6, Tumour Necrosis Factor-Alpha and Interferon-Gamma in the Fetal Murine Thymus
English
Deman, J. [> > > >]
Van Meurs, M. [> > > >]
Claassen, E. [> > > >]
Humblet, Chantal mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Defresne, Marie-Paule mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Sep-1996
Immunology
89
1
152-7
Yes (verified by ORBi)
International
0019-2805
[en] Cytokines are known to play a role in T-cell lymphopoiesis as potent growth or differentiation factors, but many experiments focusing on their role in the thymus have been conducted only in vitro. We have thus used frozen sections obtained from fetal thymuses of normal C57BL 6 mice to investigate by immunohistochemistry the presence of interleukin-1 beta (I4-1 beta), IL-2. IL-4. IL-6. interferon-7 (IFN-7) and tumour necrosis facor-alpha (TNF-alpha). The results reveal that apart from IL-2, which was not detected, all these cytokines display a time-dependent expression pattern in the normal fetal thymus. First, production of IL-4, IL-6 and TNF-alpha is detected around days 13 14; this is followed by a second wave on days 16 17, with a production of IL-1 beta, IL-4 and IL-6, and finally, just before birth (day 19), by a third wave of IL-1 beta, IL-4, IL-6, IFN-7 and TNF-alpha production. This supports the hypothesis that cytokines play a rote in T-cell lymphopoiesis.
http://hdl.handle.net/2268/75657

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