Article (Scientific journals)
In Vivo Expression of Interleukin-1 Beta (Il-1 Beta), Il-2, Il-4, Il-6, Tumour Necrosis Factor-Alpha and Interferon-Gamma in the Fetal Murine Thymus
Deman, J.; Van Meurs, M.; Claassen, E. et al.
1996In Immunology, 89 (1), p. 152-7
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Abstract :
[en] Cytokines are known to play a role in T-cell lymphopoiesis as potent growth or differentiation factors, but many experiments focusing on their role in the thymus have been conducted only in vitro. We have thus used frozen sections obtained from fetal thymuses of normal C57BL 6 mice to investigate by immunohistochemistry the presence of interleukin-1 beta (I4-1 beta), IL-2. IL-4. IL-6. interferon-7 (IFN-7) and tumour necrosis facor-alpha (TNF-alpha). The results reveal that apart from IL-2, which was not detected, all these cytokines display a time-dependent expression pattern in the normal fetal thymus. First, production of IL-4, IL-6 and TNF-alpha is detected around days 13 14; this is followed by a second wave on days 16 17, with a production of IL-1 beta, IL-4 and IL-6, and finally, just before birth (day 19), by a third wave of IL-1 beta, IL-4, IL-6, IFN-7 and TNF-alpha production. This supports the hypothesis that cytokines play a rote in T-cell lymphopoiesis.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Deman, J.
Van Meurs, M.
Claassen, E.
Humblet, Chantal ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
English
Title :
In Vivo Expression of Interleukin-1 Beta (Il-1 Beta), Il-2, Il-4, Il-6, Tumour Necrosis Factor-Alpha and Interferon-Gamma in the Fetal Murine Thymus
Publication date :
September 1996
Journal title :
Immunology
ISSN :
0019-2805
eISSN :
1365-2567
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
89
Issue :
1
Pages :
152-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 November 2010

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