No full text
Article (Scientific journals)
Spontaneous and Induced Apoptosis after Whole Body Radiation Exposure: Experimental Approaches. Observations in Radio-Induced Thymic Lymphomagenesis
Humblet, Chantal; Deman, J.; Franzen, Rachelle et al.
1995In Stem Cells, 13 (Suppl 1), p. 129-35
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] Radio-induced thymic lymphomagenesis is associated with alterations in the balance between thymocyte subsets and cytokinetic perturbations. The objectives of this work were to investigate whether these alterations are associated with alterations in the basic levels of thymocyte apoptosis. For this purpose, we tested DNA fragmentation by gel electrophoresis, analyzed DNA content by propidium iodide staining of ethanol fixed cells and looked for DNA strand breaks on tissue sections by in situ end labeling. We described an increase of the levels of apoptosis in cultured thymocytes during the preleukemic period, while the basic levels of apoptosis observed in situ are similar in normal and in preleukemic thymuses. We propose that after leukemogenic irradiations, there is an increase of cells wherein the cell suicide program is activated but that environmental thymic factors rescue them from apoptosis. Preleukemic cells could belong to this abnormally surviving population of cells "programmed to die," wherein additional genomic abnormalities would lead to fully neoplastic transformation.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Humblet, Chantal ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Deman, J.
Franzen, Rachelle  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Greimers, Roland ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques
Defresne, Marie-Paule ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie - Cytologie
Language :
English
Title :
Spontaneous and Induced Apoptosis after Whole Body Radiation Exposure: Experimental Approaches. Observations in Radio-Induced Thymic Lymphomagenesis
Publication date :
May 1995
Journal title :
Stem Cells
ISSN :
1066-5099
eISSN :
1549-4918
Publisher :
AlphaMed, Durham, United States - North Carolina
Volume :
13
Issue :
Suppl 1
Pages :
129-35
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 15 November 2010

Statistics


Number of views
42 (3 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
8
Scopus citations®
without self-citations
4

Bibliography


Similar publications



Contact ORBi