Reference : La fonction centrale du thymus dans la reconnaissance des fonctions neuroendocrines par ...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
http://hdl.handle.net/2268/75646
La fonction centrale du thymus dans la reconnaissance des fonctions neuroendocrines par les lymphocytes T au cours de leur développement
French
[en] Central Function of the Thymus in the Recognition of Neuroendocrine Functions by T Lymphocytes During Their Development
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie >]
Martens, Henri mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Embryologie >]
Cormann-Goffin, N. [> > > >]
Vandersmissen, E. [> > > >]
Legros, Jean-Jacques mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
De Groote, D. [> > > >]
Defresne, Marie-Paule mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >]
Boniver, Jacques mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques]
Franchimont, P. [> > > >]
1993
Archives Internationales de Physiologie, de Biochimie et de Biophysique
101
4, Jul-Aug
A19-22
Yes (verified by ORBi)
International
0778-3124
[en] The dual physiological role of the thymus in T cell positive and negative selection appears prominent in the establishment of appropriate host immune defenses. However, the cellular and molecular mechanisms underlying those thymic functions begin only to be understood. On the basis of our previous investigations about the thymic expression of different neuroendocrine-related signals, we have advanced a model which transposes at the peptide level the intervention of this primary lymphoid organ in both T cell positive and negative selective processes. There is now ample evidence that the thymic subcapsular and medullary epithelium is the site for synthesis of neurohypophysial (NHP)-related peptides (reviewed in Geenen et al., 1992a). We have also demonstrated that the epithelial component of thymic "nurse" cells (TNC) synthesizes NHP-related peptides and expresses a neuroendocrine-like phenotype (Geenen et al., 1988a). This observation was a remarkable example of the intimate neuroendocrine-immune interactions that take place during T cell ontogeny. Further immunocytochemical analyses have confirmed that one dominant NHP-related epitope belongs to the oxytocin (OT) lineage of the NHP peptide superfamily (Robert et al., 1991, 1992). The intrathymic coexpression of this OT-like epitope with a neurophysin protein domain is a strong argument for a local synthetic process similar to the hypothalamo-NHP one. However, the absence of ir-OT in secretory granules of thymic epithelial cells (TEC), as well as of NHP-related peptides in the supernatant of TEC cultures questioned the application to the thymus of the classical neurosecretory model established for hypothalamic magnocellular neurons (Scharrer
http://hdl.handle.net/2268/75646

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