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| Reference : P53, Bax and Bcl-2 in Vivo Expression in the Murine Thymus after Apoptogenic Treatments |
| Scientific journals : Article | |||
| Life sciences : Anatomy (cytology, histology, embryology...) & physiology | |||
| http://hdl.handle.net/2268/75639 | |||
| P53, Bax and Bcl-2 in Vivo Expression in the Murine Thymus after Apoptogenic Treatments | |
| English | |
| Denis, Ghislaine [ > > ] | |
Humblet, Chantal  [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >] | |
| Verlaet, Myriam [Université de Liège - ULg > Services généraux (Faculté de médecine) > Service administratif de la Faculté (Médecine) >] | |
| Boniver, Jacques [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques] | |
| Defresne, Marie-Paule [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie - Cytologie >] | |
| 1998 | |
| Anticancer Research | |
| JG Delinassios Anticancer Research | |
| 18 | |
| 5, Sep-Oct | |
| 3315-21 | |
| International | |
| 0250-7005 | |
| Athens | |
| Greece | |
| [en] BACKGROUND: Neoplasia can results from a lack of cell elimination by apoptosis. In order to determine if mechanisms controlling apoptosis are disturbed during neoplastic transformation in a model of murine radio-induced thymic lymphomas, we have assessed the kinetics of p53, Bax and Bcl-2 in situ expression after induction of thymic apoptosis by irradiation or glucocorticoids at first in normal mice. MATERIALS AND METHODS: TUNEL method was used for in situ detection of apoptosis and protein expression was determined by indirect immunohistochemistry. RESULTS: After hydrocortisone injection, levels of p53 and Bax, but not Bcl-2, expression were raised. A whole body sublethal irradiation led to an increase of p53 and Bcl-2, but not Bax, expression. CONCLUSIONS: This is the first in vivo report of in situ protein expression in the thymus after apoptogenic treatments of mice. The results suggest that Bax could be involved in glucocorticoid-mediated apoptosis. The increased levels of Bcl-2 expression are discussed. | |
| http://hdl.handle.net/2268/75639 |
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